Meta-Analysis
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 14, 2016; 22(10): 3038-3051
Published online Mar 14, 2016. doi: 10.3748/wjg.v22.i10.3038
Hepatitis B virus and hepatitis C virus play different prognostic roles in intrahepatic cholangiocarcinoma: A meta-analysis
Zheng Wang, Yuan-Yuan Sheng, Qiong-Zhu Dong, Lun-Xiu Qin
Zheng Wang, Qiong-Zhu Dong, Lun-Xiu Qin, Department of Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China
Yuan-Yuan Sheng, Institute of Biomedical Sciences, Fudan University, Shanghai 200032, China
Author contributions: Wang Z, Sheng YY and Dong QZ contributed equally to this work; Qin LX, Dong QZ and Wang Z conceived and designed the study; Wang Z and Sheng YY performed the research; Wang Z and Sheng YY analyzed the data; Wang Z contributed the analysis tools; Wang Z and Dong QZ wrote the paper; and Qin LX and Dong QZ helped edit the manuscript.
Supported by National Key Projects for Infectious Diseases of China, No. 2012ZX10002-012; National Key Basic Research Program of China, No. 2013CB910500; and NSFC Program of International Cooperation and Exchanges, No. 81120108016.
Conflict-of-interest statement: The authors have declared that no conflicts of interest exist.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Lun-Xiu Qin, MD, PhD, Department of Surgery, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai 200040, China. qin_lx@yahoo.com
Telephone: +86-21-54237965 Fax: +86-21-54237965
Received: March 19, 2015
Peer-review started: March 20, 2015
First decision: June 2, 2015
Revised: June 12, 2015
Accepted: November 13, 2015
Article in press: November 13, 2015
Published online: March 14, 2016
Processing time: 351 Days and 7.9 Hours
Core Tip

Core tip: This research is the first comprehensive meta-analysis and systematic review to identify the prognostic significance of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in intrahepatic cholangiocarcinoma. According to this study, HBV infection predicted a favorable prognosis; however, HCV infection was correlated with shortened overall survival. These findings will provide useful information for clinical decision-making in patients with intrahepatic cholangiocarcinoma.