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Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 7, 2016; 22(1): 326-337
Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.326
Targeting adeno-associated virus and adenoviral gene therapy for hepatocellular carcinoma
Yi-Gang Wang, Pan-Pan Huang, Rong Zhang, Bu-Yun Ma, Xiu-Mei Zhou, Yan-Fang Sun
Yi-Gang Wang, Pan-Pan Huang, Rong Zhang, Bu-Yun Ma, Xiu-Mei Zhou, Yan-Fang Sun, Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang Province, China
Author contributions: Wang YG, Huang PP and Sun YF performed the literature, and drafted the manuscript; Zhang R, Ma BY and Zhou XM revised the manuscript; and all the authors have read and approved the final version to be published.
Supported by National Natural Science Foundation of China. No. 81272687; Zhejiang Provincial Public Welfare Technology Application Research Projects, No. 2014C33275; Zhejiang Provincial Natural Science Foundation of China, No. LZ13H160004; and the Grant for 521 Talent Project of Zhejiang Sci-Tech University, Hangzhou, China.
Conflict-of-interest statement: The authors declare that there is no conflict of interest related to this study.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Yi-Gang Wang, Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci-Tech University, No. 5, Road 2, Xiasha District, Hangzhou 310018, Zhejiang Province, China. wangyigang43@163.com
Telephone: +86-571-86843187 Fax: +86-571-86843185
Received: May 27, 2015
Peer-review started: May 29, 2015
First decision: August 31, 2015
Revised: September 14, 2015
Accepted: September 30, 2015
Article in press: September 30, 2015
Published online: January 7, 2016
Processing time: 217 Days and 13.9 Hours
Core Tip

Core tip: This review summarizes the basic knowledge, current advances, and future challenges and prospects of adeno-associated virus (AAV) and adenoviruses as vectors for gene therapy of hepatocellular carcinoma. This paper also reviews the clinical trials of gene therapy using adenovirus vectors, immunotherapy, toxicity and immunological barriers for AAV and adenoviruses, and proposes several alternative strategies to overcome the therapeutic barriers to using AAV and adenoviruses as vectors.