©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2015; 21(9): 2614-2621
Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2614
Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2614
Contrast-enhanced ultrasonography for the evaluation of liver fibrosis after biliary obstruction
Hyun Joo Shin, Hyun Gi Kim, Myung-Joon Kim, Mi-Jung Lee, Department of Radiology and Research Institute of Radiological Science, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul 120-752, South Korea
Eun Young Chang, Department of Pediatric Surgery, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul 120-752, South Korea
Hye Sun Lee, Jung Hwa Hong, Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul 120-752, South Korea
Gyuri Park, Department of Laboratory Animal Resources, Avison BioMedical Research Center, Yonsei University College of Medicine, Seoul 120-752, South Korea
Author contributions: Lee MJ designed the research; Shin HJ, Chang EY, Park G and Lee MJ performed the research; Shin HJ, Lee HS, Hong JH and Lee MJ contributed analytic tools; Shin HJ, Lee HS, Hong JH and Lee MJ analyzed the data; Shin HJ and Lee MJ wrote the paper; Shin HJ, Kim HG, Kim MJ and Lee MJ revised and approved the final version.
Supported by Faculty Research Grant of Yonsei University College of Medicine for 2013, No. 6-2013-0040.
Correspondence to: Mi-Jung Lee, MD, PhD, Department of Radiology and Research Institute of Radiological Science, Severance Children’s Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, South Korea. mjl1213@yuhs.ac
Telephone: +82-2-22287400 Fax: +82-2-3933035
Received: September 12, 2014
Peer-review started: September 13, 2014
First decision: October 14, 2014
Revised: October 24, 2014
Accepted: November 7, 2014
Article in press: November 11, 2014
Published online: March 7, 2015
Processing time: 178 Days and 4.3 Hours
Peer-review started: September 13, 2014
First decision: October 14, 2014
Revised: October 24, 2014
Accepted: November 7, 2014
Article in press: November 11, 2014
Published online: March 7, 2015
Processing time: 178 Days and 4.3 Hours
Core Tip
Core tip: Contrast-enhanced ultrasonography (CEUS) was proposed for the evaluation of liver fibrosis. However, no previous studies have evaluated the utility of CEUS for liver fibrosis caused by biliary obstruction, which can be the major cause of liver fibrosis in children. Therefore, we investigated the feasibility of CEUS to evaluate liver fibrosis from biliary obstruction by quantitatively assessing perfusion changes in an animal model with bile duct ligation. We also demonstrated that the parameter of peak signal intensity from CEUS could be useful to evaluate liver fibrosis from biliary obstruction.