Retrospective Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2015; 21(7): 2108-2115
Published online Feb 21, 2015. doi: 10.3748/wjg.v21.i7.2108
Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis
Yasuharu Maeda, Kazuo Ohtsuka, Shin-ei Kudo, Kunihiko Wakamura, Yuichi Mori, Noriyuki Ogata, Yoshiki Wada, Masashi Misawa, Akihiro Yamauchi, Seiko Hayashi, Toyoki Kudo, Takemasa Hayashi, Hideyuki Miyachi, Fuyuhiko Yamamura, Fumio Ishida, Haruhiro Inoue, Shigeharu Hamatani
Yasuharu Maeda, Kazuo Ohtsuka, Shin-ei Kudo, Kunihiko Wakamura, Yuichi Mori, Noriyuki Ogata, Yoshiki Wada, Masashi Misawa, Akihiro Yamauchi, Seiko Hayashi, Toyoki Kudo, Takemasa Hayashi, Hideyuki Miyachi, Fuyuhiko Yamamura, Fumio Ishida, Haruhiro Inoue, Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa 2248503, Japan
Kazuo Ohtsuka, Yoshiki Wada, Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University Hospital, Tokyo 1130034, Japan
Fuyuhiko Yamamura, Endoscopy Center, Showa Hospital, Tokyo 1428666, Japan
Shigeharu Hamatani, Department of Pathology, Showa University Northern Yokohama Hospital, Kanagawa 2248503, Japan
Author contributions: Maeda Y, Ohtsuka K and Wakamura K designed the research; Ohtsuka K, Misawa M, Yamauchi A, Hayashi S, Kudo T, Hayashi T, Miyachi H, Yamamura F and Hamatani S performed the research; Maeda Y, Mori Y, Ogata N and Misawa M analyzed the data and provided administrative, technical, and material support; Wada Y contributed the new analytic tool, Kudo S, Ishida F and Inoue H supervised the study; Maeda Y and Ohtsuka K wrote the paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shin-ei Kudo, MD, Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Kanagawa 2248503, Japan. kudos@med.showa-u.ac.jp
Telephone: +81-45-9497000 Fax: +81-45-9497263
Received: July 15, 2014
Peer-review started: July 15, 2014
First decision: August 15, 2014
Revised: August 26, 2014
Accepted: October 14, 2014
Article in press: October 15, 2014
Published online: February 21, 2015
Processing time: 211 Days and 9.9 Hours
Core Tip

Core tip: Endocytoscopic narrow-band imaging (EC-NBI) is a new technique, in which ultramagnified EC images are used in combination with NBI. The EC-NBI finding associated with the capillaries showed strong correlations with the presence of histological inflammation and the ability to distinguish between inactive and active ulcerative colitis. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the EC-NBI findings for diagnosing acute inflammation were 84.0%, 100%, 87.1%, 100% and 92.3%, respectively. Compared with conventional endoscopy, EC-NBI was superior in diagnostic specificity, negative predictive value, and accuracy.