Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2015; 21(7): 2047-2057
Published online Feb 21, 2015. doi: 10.3748/wjg.v21.i7.2047
Impact of high glucose on metastasis of colon cancer cells
Cheng-Yao Lin, Chih-Hui Lee, Chien-Cheng Huang, Song-Tay Lee, How-Ran Guo, Shih-Bin Su
Cheng-Yao Lin, Division of Hematology-Oncology, Department of Internal Medicine, Chi Mei Medical Center, Liouying, Tainan 736, Taiwan
Cheng-Yao Lin, Department of Dental Laboratory Technology, Min-Hwei College of Health Care Management, Tainan 736, Taiwan
Chih-Hui Lee, Department of Public Health, National Cheng Kung University, Tainan 701, Taiwan
Chien-Cheng Huang, Department of Emergency Medicine, Chi-Mei Medical Center, Tainan 710, Taiwan
Chien-Cheng Huang, Department of Child Care and Education, Southern Taiwan University of Science and Technology, Tainan 710, Taiwan
Song-Tay Lee, Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 710, Taiwan
How-Ran Guo, Department of Environmental and Occupational Health, National Cheng Kung University, Tainan 701, Taiwan
Shih-Bin Su, Department of Occupational Medicine, Chi-Mei Medical Center, Tainan 710, Taiwan
Shih-Bin Su, Department of Medical Research, Chi Mei Medical Center, Liouying, Tainan 736, Taiwan
Author contributions: Lin CY and Su SB designed the research; Lin CY, Lee ST and Huang CC performed the research; Lin CY, Lee CH, Huang CC and Guo HR contributed analyzed data; and Lin CY, Lee CH and Su SB wrote the paper.
Supported by Chi-Mei Medical Center Grant, No. CMFHR10252
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shih-Bin Su, MD, PhD, Department of Occupational Medicine, Chi-Mei Medical Center, 901 Zhonghua Road, Yung-Kang District, Tainan 710, Taiwan. 880601@mail.chimei.org.tw
Telephone: +886-6-2812811 Fax: +886-6-2816161
Received: June 23, 2014
Peer-review started: June 23, 2014
First decision: June 23, 2014
Revised: August 6, 2014
Accepted: November 18, 2014
Article in press: November 19, 2014
Published online: February 21, 2015
Processing time: 233 Days and 10.4 Hours
Core Tip

Core tip: It has been known from several epidemiological reports that colorectal cancer patients with comorbid diabetes have poor outcomes. The high glucose status in diabetes patients may play an important role in this process, but the possible mechanism is unclear. Our study reveals that glucose can promote colorectal cell migration and invasion, and the signal transducer and activator of transcription 3 induced matrix metalloproteinase-9 expression is involved in this process.