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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2015; 21(7): 2005-2010
Published online Feb 21, 2015. doi: 10.3748/wjg.v21.i7.2005
Published online Feb 21, 2015. doi: 10.3748/wjg.v21.i7.2005
Injury-associated reacquiring of intestinal stem cell function
Ferenc Sipos, Györgyi Műzes, 2nd Department of Internal Medicine, Semmelweis University, 1088 Budapest, Hungary
Author contributions: Sipos F and Műzes G contributed to writing, editing and revising of this paper.
Conflict-of-interest: All authors declare no conflict of interest regarding our manuscript “Injury-associated reacquiring of stem cell function”.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ferenc Sipos, MD, PhD, 2nd Department of Internal Medicine, Semmelweis University, Szentkirályi str. 46, 1088 Budapest, Hungary. dr.siposf@gmail.com
Telephone: +36-12-660926 Fax: +36-12-660816
Received: October 1, 2014
Peer-review started: October 3, 2014
First decision: October 29, 2014
Revised: November 4, 2014
Accepted: January 8, 2015
Article in press: January 8, 2015
Published online: February 21, 2015
Processing time: 133 Days and 0.3 Hours
Peer-review started: October 3, 2014
First decision: October 29, 2014
Revised: November 4, 2014
Accepted: January 8, 2015
Article in press: January 8, 2015
Published online: February 21, 2015
Processing time: 133 Days and 0.3 Hours
Core Tip
Core tip: The cellular plasticity and lineage reversibility of the epithelial layer may represent adaptive mechanisms for the self-preservation of the epithelial layer after injuries. Recent results revealed that a portion of Lgr5-expressing intestinal cells cycles less frequently, and upon physiological circumstances does not contribute to intestinal homeostasis, however, they reacquire stem cell function and can be recruited to serve as a functional clonogenic stem population after injury.