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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2015; 21(6): 1749-1758
Published online Feb 14, 2015. doi: 10.3748/wjg.v21.i6.1749
Published online Feb 14, 2015. doi: 10.3748/wjg.v21.i6.1749
Immunohistochemical expression of SP-NK-1R-EGFR pathway and VDR in colonic inflammation and neoplasia
Raymond A Isidro, Myrella L Cruz, Angel A Isidro, Caroline B Appleyard, Department of Physiology and Pharmacology, Ponce School of Medicine and Health Sciences, Ponce, PR 00732, United States
Angel A Isidro, Axel Baez, Department of Pathology, Ponce School of Medicine and Health Sciences, Ponce, PR 00732, United States
Axel Arroyo, Department of Anatomy, Ponce School of Medicine and Health Sciences, Ponce, PR 00732, United States
William A González-Marqués, Carmen González-Keelan, Departments of Pathology and Laboratory Medicine, University of Puerto Rico School of Medicine, San Juan, PR 00936, United States
Esther A Torres, Department of Medicine, University of Puerto Rico School of Medicine, San Juan, PR 00936, United States
Author contributions: Isidro RA, Isidro AA, Arroyo A, Torres EA and Appleyard CB designed the research; Isidro RA, Cruz ML, Isidro AA and Appleyard CB performed the research; Baez A, Arroyo A, González-Marqués WA, González-Keelan C and Torres EA identified and provided tissue samples; Isidro RA, Cruz ML and Appleyard CB analyzed the data; Isidro RA drafted the manuscript; Cruz ML, Isidro AA, Baez A, Arroyo A, Gonzalez-Marqués WA, González-Keelan C, Torres EA and Appleyard CB critically revised manuscript for important intellectual content.
Supported by National Institutes of Health Grants, No. U56 CA126379 (to Isidro AA and Appleyard CB) and No. R25-GM082406 (to Isidro RA); and National Science Foundation: Puerto Rico Louis Stokes Alliance for Minority Participation, NSF Project No. 0601843 (to Isidro RA); The PSMHS Molecular Biology Core Lab, RCMI Grant No. RR003050/MD007579.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Caroline B Appleyard, PhD, Professor, Department of Physiology and Pharmacology, Ponce School of Medicine and Health Sciences, PO Box 7004, Ponce, PR 00732-7004, United States. cappleyard@psm.edu
Telephone: +1-787-8402575 Fax: +1-787-8411040
Received: August 6, 2014
Peer-review started: August 8, 2014
First decision: September 15, 2014
Revised: September 27, 2014
Accepted: November 18, 2014
Article in press: November 19, 2014
Published online: February 14, 2015
Processing time: 188 Days and 18 Hours
Peer-review started: August 8, 2014
First decision: September 15, 2014
Revised: September 27, 2014
Accepted: November 18, 2014
Article in press: November 19, 2014
Published online: February 14, 2015
Processing time: 188 Days and 18 Hours
Core Tip
Core tip: This study compares for the first time the expression of neurokinin-1 receptor, phosphorylated epidermal growth factor receptor, cyclooxygenase-2, and vitamin D receptor in samples from patients with sporadic colorectal neoplasia, colitis, and colitis-associated colorectal neoplasia and obtained from a Puerto Rican population. We believe that this knowledge could be of great use for the further identification of reliable markers of cancer risk and of potential therapeutic targets in a population where colorectal cancer is the deadliest cancer, and that our findings could be used in the day-to-day examination of colonic biopsies for establishing a diagnosis and distinguishing dysplasia from reactive inflammatory changes.