©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2015; 21(5): 1663-1665
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1663
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1663
High-grade dysplasia, restricted to the basal cell layer involving the entire esophagus
Mario Sarbia, Diana Karimi, Pathology Munich-North, 80992 Munich, Germany
Stefan Wolfer, Practice for Diagnostic Endoscopy in Stomach and Gut Diseases, 80796 Munich, Germany
Albert Eimiller, Clinic for Gastrointestinal Diseases, 80331 Munich, Germany
Author contributions: Wolfer S and Eimiller A substantially contributed to the acquisition and analysis of data; Karimi D analyzed the data and contributed to the acquisition of data; Sarbia M wrote the paper; all authors approved the final version of the manuscript.
Correspondence to: Mario Sarbia, Professor, Pathology Munich-North, Ernst-Platzstrasse 2, 80992 Munich, Germany. sarbia@pathologie-muenchen.de
Telephone: +49-89-127340 Fax: +49-89-12737474
Received: June 2, 2014
Peer-review started: June 3, 2014
First decision: August 15, 2014
Revised: September 25, 2014
Accepted: November 19, 2014
Article in press: November 19, 2014
Published online: February 7, 2015
Processing time: 251 Days and 23.3 Hours
Peer-review started: June 3, 2014
First decision: August 15, 2014
Revised: September 25, 2014
Accepted: November 19, 2014
Article in press: November 19, 2014
Published online: February 7, 2015
Processing time: 251 Days and 23.3 Hours
Core Tip
Core tip: An unusual case of high-grade squamous cell dysplasia involving the entire esophagus with dysplastic cells located exclusively in the basal portion of the esophageal squamous epithelium is reported. The analyses of results from step-biopsies of the entire esophagus were obtained using histologic and immunohistochemical analyses. Molecular pathologic analysis showed mutation of the p53 gene. The current World Health Organization (WHO) definition of high-grade squamous dysplasia requires full-thickness involvement of the squamous epithelium, which was not present in the current case. Therefore, we recommend that the WHO criteria should be reconsidered and revised.