©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2015; 21(5): 1479-1487
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1479
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1479
Xiaotan Sanjie decoction inhibits interleukin-8-induced metastatic potency in gastric cancer
Jun Shi, Pin-Kang Wei, Department of Traditional Chinese Medicine, Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China
Author contributions: Wei PK designed the research; Shi J performed the research and wrote the paper.
Supported by Grant from the three-year action plan fund of Traditional Chinese Medicine, Shanghai City Health Administration, China, No. ZYSNXD-CC-ZDYJ024.
Correspondence to: Pin-Kang Wei, Professor, Department of Traditional Chinese Medicine, Shanghai Changzheng Hospital, The Second Military Medical University, No.415 Fengyang Road, Huangpu District, Shanghai 200003, China. czzyk73408@163.com
Telephone: +86-21-81885471 Fax: +86-21-63520020
Received: August 4, 2014
Peer-review started: August 5, 2014
First decision: August 27, 2014
Revised: September 9, 2014
Accepted: October 15, 2014
Article in press: October 15, 2014
Published online: February 7, 2015
Processing time: 189 Days and 1.4 Hours
Peer-review started: August 5, 2014
First decision: August 27, 2014
Revised: September 9, 2014
Accepted: October 15, 2014
Article in press: October 15, 2014
Published online: February 7, 2015
Processing time: 189 Days and 1.4 Hours
Core Tip
Core tip: SGC-7901 gastric cancer cells were used to evaluate the effects of Xiaotan Sanjie (XTSJ) decoction on adhesion, migration and invasion of gastric cancer cells and the role of interleukin-8 (IL-8) in these effects in vitro. This study focused on the interaction between XTSJ decoction and IL-8. XTSJ decoction significantly inhibited adhesion, migration and invasion of SGC-7901 cells, which was partly associated with down-regulation of IL-8. The results reflect the therapeutic potential of XTSJ decoction for preventing metastasis of gastric cancer.