Niu JX, Meng XK, Ren JJ. Studied microRNA gene expression in human hepatocellular carcinoma by microRNA microarray techniques. World J Gastroenterol 2015; 21(44): 12605-12611 [PMID: 26640336 DOI: 10.3748/wjg.v21.i44.12605]
Corresponding Author of This Article
Dr. Jian-Jun Ren, Department of General Surgery of the Affiliated Hospital of Inner Mongolia Medical University, No. 42 Zhaowuda Road, Saihan Region, Huhehaote 010010, Inner Mongolia Autonomous Region, China. renjianjunzml@163.com
Research Domain of This Article
Allergy
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
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World J Gastroenterol. Nov 28, 2015; 21(44): 12605-12611 Published online Nov 28, 2015. doi: 10.3748/wjg.v21.i44.12605
Studied microRNA gene expression in human hepatocellular carcinoma by microRNA microarray techniques
Jian-Jun Ren, Xing-Kai Meng, Jian-Xiang Niu
Jian-Xiang Niu, Xing-Kai Meng, Jian-Jun Ren, Department of General Surgery of the Affiliated Hospital of Inner Mongolia Medical University, Huhehaote 010010, Inner Mongolia Autonomous Region, China
Author contributions: Niu JX and Ren JJ designed the research; Niu JX and Meng XK performed the research; Niu JX contributed new reagents; Meng XK contributed analytical tools; Niu JX and Ren JJ analyzed the data; Niu JX wrote the paper.
Supported by Inner Mongolia Medical College Millions of Science and Technology Project in 2011, No. NY2011bw004; the 2010 Inner Mongolia Health Bureau of Medical and Health Research Project, No. 2010038; Scientific Research Projects of the Inner Mongolia Autonomous Region High School in 2013, No. NJZY13416.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Inner Mongolia Medical College.
Informed consent statement: All patients involved had previously provided their written, informed consent to have their clinical and pathogenic information used for research.
Conflict-of-interest statement: There was no conflict of interest for any of the authors.
Data sharing statement: There was no discussion of data sharing or its implications for the study participants.
Correspondence to: Dr. Jian-Jun Ren, Department of General Surgery of the Affiliated Hospital of Inner Mongolia Medical University, No. 42 Zhaowuda Road, Saihan Region, Huhehaote 010010, Inner Mongolia Autonomous Region, China. renjianjunzml@163.com
Telephone: +86-471-3280800
Received: May 24, 2015 Peer-review started: May 25, 2015 First decision: June 25, 2015 Revised: July 26, 2015 Accepted: October 12, 2015 Article in press: October 13, 2015 Published online: November 28, 2015 Processing time: 186 Days and 14.8 Hours
Core Tip
Core tip: There was a better understanding of the molecular mechanisms of microRNA (miRNA) expression changes involved in hepatocellular carcinoma, associated patients with aggressive malignancy and poor prognosis. The 35 hepatitis B virus cases were divided into two groups, a hepatocirrhosis group with 20 cases and a liver cancer group with 15 cases. 12 healthy people were used as a control. There were significant changes in miRNA expression between the three groups. miRNA-183 was the most up-regulated, followed by miRNA-373. miRNA-129 and miRNA-188 were both strongly down-regulated and miRNA-378 was down-regulated a small amount. The liver cancer group had greater changes, which indicated that changes in miRNA expression levels were caused by hepatocirrhosis. The liver cancer disease course then further increased these changes.
