©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 7, 2015; 21(41): 11815-11824
Published online Nov 7, 2015. doi: 10.3748/wjg.v21.i41.11815
Published online Nov 7, 2015. doi: 10.3748/wjg.v21.i41.11815
Inflammation: A novel target of current therapies for hepatic encephalopathy in liver cirrhosis
Ming Luo, Jian-Yang Guo, Department of Gastroenterology, Ningxia People’s Hospital, Yinchuan 750021, Ningxia Hui Autonomous Region, China
Wu-Kui Cao, Tianjin Liver Disease Institute, Tianjin Second People’s Hospital, Tianjin 300192, China
Author contributions: Cao WK designed the study and outlined the draft; Luo M wrote and organized the manuscript; and Guo JY searched the reference materials and contributed to the writing of the manuscript.
Conflict-of-interest statement: The authors have no conflicts of interest to declare in relation to this manuscript.
Correspondence to: Wu-Kui Cao, PhD, Tianjin Liver Disease Institute, Tianjin Second People’s Hospital, No. 75 Sudi Road, Nankai District, Tianjin 300192, China. caowukui@126.com
Telephone: +86-22-27468102
Received: April 16, 2015
Peer-review started: April 18, 2015
First decision: May 18, 2015
Revised: June 19, 2015
Accepted: September 14, 2015
Article in press: September 14, 2015
Published online: November 7, 2015
Processing time: 200 Days and 20.5 Hours
Peer-review started: April 18, 2015
First decision: May 18, 2015
Revised: June 19, 2015
Accepted: September 14, 2015
Article in press: September 14, 2015
Published online: November 7, 2015
Processing time: 200 Days and 20.5 Hours
Core Tip
Core tip: Currently, inflammation appears to play a critical role in the pathogenesis of hepatic encephalopathy (HE) and is gradually being considered a critical therapeutic target for HE in patients with liver cirrhosis. Current therapies for HE, including lactulose, rifaximin, probiotics and the molecular adsorbent recirculating system, have been found to improve clinical manifestations and prevent the progression of HE by ameliorating inflammation in cirrhotic patients. This review will provide an overview of the inflammatory pathogenesis of HE, focusing on the recent findings on its therapeutic manipulation.