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Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 7, 2015; 21(41): 11552-11566
Published online Nov 7, 2015. doi: 10.3748/wjg.v21.i41.11552
Genetic, metabolic and environmental factors involved in the development of liver cirrhosis in Mexico
Omar Ramos-Lopez, Erika Martinez-Lopez, Sonia Roman, Nora A Fierro, Arturo Panduro
Omar Ramos-Lopez, Erika Martinez-Lopez, Sonia Roman, Nora A Fierro, Arturo Panduro, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, “Fray Antonio Alcalde”, Guadalajara, Jalisco, Mexico and Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco 44280, Mexico
Author contributions: Panduro A conceived, designed and critically revised the paper; Ramos-Lopez O and Martinez-Lopez E performed research and wrote the paper; Roman S performed research, wrote the paper and integrated the final version; Fierro NA wrote and critically reviewed the paper; all authors revised and approved the final version.
Supported by Promep-University of Guadalajara (UDG-CA-478, to Panduro A).
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Arturo Panduro, MD, PhD, FAASLD, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, “Fray Antonio Alcalde”, Guadalajara, Jalisco, Mexico and Health Sciences Center, University of Guadalajara, Hospital 278, Col. El Retiro, Guadalajara, Jalisco 44280, México. apanduro@prodigy.net.mx
Telephone: +52-33-36147743 Fax: +52-33-36147743
Received: April 28, 2015
Peer-review started: May 6, 2015
First decision: July 13, 2015
Revised: July 29, 2015
Accepted: September 14, 2015
Article in press: September 14, 2015
Published online: November 7, 2015
Processing time: 189 Days and 11.2 Hours
Core Tip

Core tip: Liver cirrhosis is a global health problem. The onset, progression, and clinical outcome of liver cirrhosis are influenced by several hereditary and lifestyle factors. Worldwide, interactions between genetic and environmental factors involved in liver cirrhosis may be associated with ethnic-based variations. Globally, in populations with admixed genomes, such as the Mexican population, individualized medicine represents a new challenge for hepatologists and gastroenterologists.