©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2015; 21(36): 10461-10467
Published online Sep 28, 2015. doi: 10.3748/wjg.v21.i36.10461
Published online Sep 28, 2015. doi: 10.3748/wjg.v21.i36.10461
Jejunitis and brown bowel syndrome with multifocal carcinogenesis of the small bowel
Martin Raithel, Alexander F Hagel, Heinz Albrecht, Thomas de Rossi, Eckhart G Hahn, Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen D-91054, Germany
Tilman T Rau, Department of Pathology, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen D-91054, Germany
Thomas Kirchner, Department of Pathology, Ludwig-Maximilians-University Munich, Munich D-80337, Germany
Author contributions: Raithel M and Hahn EG conceived of the study and wrote and revised the paper; Rau TT and Kirchner T carried out the pathologic investigations; Hagel AF, de Rossi T and Albrecht H participated in data collection and design and coordination of the study; All authors read and approved the final manuscript.
Supported by Deutsche Forschungsgemeinschaft and Friedrich-Alexander-University Erlangen-Nuremberg within the funding program Open Access Publishing.
Institutional review board statement: As the case report was written retrospectively, it was not antecedently reviewed by the local ethics committee of the Friedrich-Alexander-University Erlangen-Nuremberg.
Informed consent statement: The patient provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Correspondence to: Heinz Albrecht, MD, Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nuremberg, University Hospital Erlangen, Ulmenweg 18, Erlangen D-91054, Germany. heinz.albrecht@uk-erlangen.de
Telephone: +49-9131-8535000 Fax: +49-9131-8535252
Received: March 9, 2015
Peer-review started: March 11, 2015
First decision: March 26, 2015
Revised: May 15, 2015
Accepted: June 26, 2015
Article in press: June 26, 2015
Published online: September 28, 2015
Processing time: 202 Days and 12.5 Hours
Peer-review started: March 11, 2015
First decision: March 26, 2015
Revised: May 15, 2015
Accepted: June 26, 2015
Article in press: June 26, 2015
Published online: September 28, 2015
Processing time: 202 Days and 12.5 Hours
Core Tip
Core tip: Severe malabsorption associated with brown bowel syndrome can progress to multifocally spread small bowel adenocarcinoma. This report describes the clinical course of a woman suffering from a long-lasting malabsorption syndrome who developed small bowel adenocarcinoma in an enteritis-dysplasia-carcinoma sequence. After several decades of chronic jejunitis with malabsorption, multifocal nests of adenocarcinoma cells were found only in the small bowel without evidence of hereditary nonpolyposis colon carcinoma syndrome.