Gao Y, Zheng DY, Cui Z, Ma Y, Liu YZ, Zhang W. Predictive value of quantitative contrast-enhanced ultrasound in hepatocellular carcinoma recurrence after ablation. World J Gastroenterol 2015; 21(36): 10418-10426 [PMID: 26420968 DOI: 10.3748/wjg.v21.i36.10418]
Corresponding Author of This Article
Zheng Cui, BD, Deputy Chief Physician, Department of Ultrasound in Medicine, Tongji University Affiliated East Hospital, No. 150 Jimo Road, Shanghai 200120, China. gaoyisixth@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Clinical Trials Study
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Gao Y, Zheng DY, Cui Z, Ma Y, Liu YZ, Zhang W. Predictive value of quantitative contrast-enhanced ultrasound in hepatocellular carcinoma recurrence after ablation. World J Gastroenterol 2015; 21(36): 10418-10426 [PMID: 26420968 DOI: 10.3748/wjg.v21.i36.10418]
World J Gastroenterol. Sep 28, 2015; 21(36): 10418-10426 Published online Sep 28, 2015. doi: 10.3748/wjg.v21.i36.10418
Predictive value of quantitative contrast-enhanced ultrasound in hepatocellular carcinoma recurrence after ablation
Yi Gao, Dong-Yan Zheng, Zheng Cui, Yan Ma, Yuan-Zhi Liu, Wei Zhang
Yi Gao, Zheng Cui, Yan Ma, Department of Ultrasound in Medicine, Tongji University Affiliated East Hospital, Shanghai 200120, China
Dong-Yan Zheng, Department of Ultrasound in Medicine, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
Yuan-Zhi Liu, Department of first Gastroenterology, Capital Medical University Affiliated Beijing You’an Hospital, Beijing 100069, China
Wei Zhang, Department of Radiology, Beijing Jishuitan Hospital, Beijing 100035, China
Author contributions: Gao Y and Zheng DY contributed equally to this work; Gao Y, Zheng DY and Cui Z designed the research; Gao Y, Zheng DY, Cui Z, Ma Y, Liu YZ and Zhang W performed the research; Ma Y, Liu YZ and Zhang W contributed new reagents/analytic tools; Gao Y, Zheng DY and Cui Z analyzed the data; and Gao Y and Zheng DY wrote the paper.
Institutional review board statement: The study was reviewed and approved by the Department of Ultrasound in Medicine, Tongji University Affiliated East Hospital, Shanghai Institutional Review Board.
Clinical trial registration statement: This study is not registered as a Clinical trial as all the data were gained from an ultrasound system.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: We declare that there are no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
Correspondence to: Zheng Cui, BD, Deputy Chief Physician, Department of Ultrasound in Medicine, Tongji University Affiliated East Hospital, No. 150 Jimo Road, Shanghai 200120, China. gaoyisixth@163.com
Telephone: +86-21-38804518
Received: March 15, 2015 Peer-review started: March 15, 2015 First decision: April 13, 2015 Revised: May 28, 2015 Accepted: June 15, 2015 Article in press: June 16, 2015 Published online: September 28, 2015 Processing time: 197 Days and 1.7 Hours
Core Tip
Core tip: This study quantitatively analyzed contrast-enhanced ultrasound (CEUS) images from patients with hepatocellular carcinoma (HCC). The results showed that HCC patients who have low levels of tumor time to peak (tTTP), tumor peak intensity and tumor-parenchymal peak intensity before ablation were more likely to relapse after ablation. Expression levels of basic fibroblast growth factor (bFGF) in the recurrence group were higher than those in the non-recurrence group, and tTTP levels were negatively correlated with bFGF expression levels. This was expected to be a predictable index for HCC recurrence after ablation. The results also revealed that CEUS is a non-invasive and effective method for evaluating HCC angiogenesis, its recurrence and metastasis.
