Mori S, Fujiyama S. Hepatitis B virus reactivation associated with antirheumatic therapy: Risk and prophylaxis recommendations. World J Gastroenterol 2015; 21(36): 10274-10289 [PMID: 26420955 DOI: 10.3748/wjg.v21.i36.10274]
Corresponding Author of This Article
Shunsuke Mori, MD, PhD, Department of Rheumatology, Clinical Research Center for Rheumatic Diseases, NHO Kumamoto Saishunsou National Hospital, 2659 Suya, Kohshi, Kumamoto 861-1196, Japan. moris@saisyunsou1.hosp.go.jp
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Gastroenterology & Hepatology
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Topic Highlight
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Mori S, Fujiyama S. Hepatitis B virus reactivation associated with antirheumatic therapy: Risk and prophylaxis recommendations. World J Gastroenterol 2015; 21(36): 10274-10289 [PMID: 26420955 DOI: 10.3748/wjg.v21.i36.10274]
World J Gastroenterol. Sep 28, 2015; 21(36): 10274-10289 Published online Sep 28, 2015. doi: 10.3748/wjg.v21.i36.10274
Hepatitis B virus reactivation associated with antirheumatic therapy: Risk and prophylaxis recommendations
Shunsuke Mori, Shigetoshi Fujiyama
Shunsuke Mori, Department of Rheumatology, Clinical Research Center for Rheumatic Diseases, NHO Kumamoto Saishunsou National Hospital, Kumamoto 861-1196, Japan
Shigetoshi Fujiyama, Department of Hepatology and Gastroenterology, Kumamoto Shinto General Hospital, Kumamoto 862-8655, Japan
Author contributions: All authors contributed to the study concept and design, acquisition of data, analysis and interpretation of data, drafting of the manuscript and making critical revisions with regard to important intellectual content, and final approval of the manuscript.
Supported by Research funds from the National Hospital Organization, Japan.
Conflict-of-interest statement: Dr. Shunsuke Mori has received research grants from Chugai Pharmaceutical Co., Bristol-Myers Squibb, Eisai Pharmaceutical Co., Ltd., Mitsubishi Tanabe Pharma Corporation, Pfizer Japan Inc., and Astellas Pharma Inc. Dr. Shigetoshi Fujiyama has no financial relationships that could lead to a conflict of interest.
Correspondence to: Shunsuke Mori, MD, PhD, Department of Rheumatology, Clinical Research Center for Rheumatic Diseases, NHO Kumamoto Saishunsou National Hospital, 2659 Suya, Kohshi, Kumamoto 861-1196, Japan. moris@saisyunsou1.hosp.go.jp
Telephone: +81-96-2421000 Fax: +81-96-2422619
Received: April 1, 2015 Peer-review started: April 2, 2015 First decision: June 2, 2015 Revised: June 20, 2015 Accepted: August 25, 2015 Article in press: August 25, 2015 Published online: September 28, 2015 Processing time: 180 Days and 1.5 Hours
Core Tip
Core tip: In the literature, the prevalence of resolved hepatitis B virus (HBV) infection varied in rheumatic disease patients, ranging from 7.3% to 66%, which seems to be related directly to the general prevalence of HBV infection in the respective geographic areas. When calculated using data from observational cohort studies, the incidence rate was 1.7% in rheumatic disease patients receiving biological therapy and 3.2% in those treated with non-biological drugs. In antirheumatic therapy, multiple immunosuppressants are administered during long periods. Optimal frequency and duration of HBV-DNA monitoring and reliable markers for discontinuation of nucleoside analogues remain unclear for rheumatic disease patients with resolved HBV infection.
