©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2015; 21(31): 9430-9436
Published online Aug 21, 2015. doi: 10.3748/wjg.v21.i31.9430
Published online Aug 21, 2015. doi: 10.3748/wjg.v21.i31.9430
Helicobacter pylori and gastric mucin expression: A systematic review and meta-analysis
Yaron Niv, Department of Gastroenterology, Rabin Medical Center, Tel Aviv University, Petach Tikva 49100, Israel
Author contributions: Niv Y solely contributed to this paper.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: No additional data available.
Correspondence to: Yaron Niv, MD, AGAF, FACG, Professor, Department of Gastroenterology, Rabin Medical Center, Tel Aviv University, 39 Jabotinski Street, Petach Tikva 49100, Israel. yniv@clalit.org.il
Telephone: +972-3-9377237 Fax: +972-3-9210313
Received: March 7, 2015
Peer-review started: March 11, 2015
First decision: April 13, 2015
Revised: April 22, 2015
Accepted: June 16, 2015
Article in press: June 16, 2015
Published online: August 21, 2015
Processing time: 165 Days and 21.4 Hours
Peer-review started: March 11, 2015
First decision: April 13, 2015
Revised: April 22, 2015
Accepted: June 16, 2015
Article in press: June 16, 2015
Published online: August 21, 2015
Processing time: 165 Days and 21.4 Hours
Core Tip
Core tip: In this meta-analysis we looked at studies that investigated the relationship between Helicobacter pylori (H. pylori) and mucin expression in the human gastric mucosa. English Medical literature searches were conducted for studies comparing mucin expression in the gastric mucosa in patients positive and negative for H. pylori infection. Meta-analysis was performed, and pooled odds ratios were calculated compared mucin expression in individual studies. Eleven studies, which represent 53 sub studies of 15 different kinds of mucin, were found. H. pylori inhibited MUC5AC expression and facilitated colonization. In contrast, increased MUC6 expression may help inhibiting colonization, using MUC6 antibiotics properties.