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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2015; 21(31): 9262-9272
Published online Aug 21, 2015. doi: 10.3748/wjg.v21.i31.9262
Published online Aug 21, 2015. doi: 10.3748/wjg.v21.i31.9262
Role of phytochemicals in colorectal cancer prevention
Yu-Hua Li, Yang Sun, Feng Zhang, Lei Fan, Qi-Bing Mei, Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Collaborative Innovation Center for Chinese Medicine in Qinba Mountains, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China
Yu-Hua Li, No. 181 Hospital of PLA, Guilin 541002, Guangxi Zhuang Autonomous Region, China
Yin-Bo Niu, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, Shaanxi Province, China
Chang-Xu Liu, No. 303 Hospital of PLA, Nanning 530022, Guangxi Zhuang Autonomous Region, China
Author contributions: Li YH and Mei QB did problem formulation; Niu YB, Sun Y and Fan L performed literature search; Li YH, Zhang F, and Liu CX wrote the paper.
Supported by Postdoctoral Science Foundation of China, No. 2012M512102, No. 2013T60964; and National Nature Science Foundation of China, No. 81302787.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Qi-Bing Mei, PhD, Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Collaborative Innovation Center for Chinese Medicine in Qinba Mountains, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, No. 169 Changle West Road, Xi’an 710032, Shaanxi Province, China. qbmei53@hotmail.com
Telephone: +86-29-84779212 Fax: +86-29-84779212
Received: March 27, 2015
Peer-review started: March 28, 2015
First decision: April 28, 2014
Revised: May 9, 2015
Accepted: July 15, 2015
Article in press: July 15, 2015
Published online: August 21, 2015
Processing time: 145 Days and 22.1 Hours
Peer-review started: March 28, 2015
First decision: April 28, 2014
Revised: May 9, 2015
Accepted: July 15, 2015
Article in press: July 15, 2015
Published online: August 21, 2015
Processing time: 145 Days and 22.1 Hours
Core Tip
Core tip: Colorectal cancer (CRC) remains a major public health issue as a leading cause of cancer mortality and morbidity worldwide. Chemoprevention is one milestone for this disease. A diet consisting of fruits, vegetables, and spices has the potential to prevent CRC. This manuscript reviews the phytochemicals in these dietary foods that are responsible for preventing CRC and the possible mechanisms. Various phytochemicals have been identified in fruits, vegetables, and spices which exhibit chemopreventive potential. This work will further promote the importance of phytochemicals in CRC prevention.