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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 14, 2015; 21(30): 9055-9066
Published online Aug 14, 2015. doi: 10.3748/wjg.v21.i30.9055
Published online Aug 14, 2015. doi: 10.3748/wjg.v21.i30.9055
Calcium glycerophosphate preserves transepithelial integrity in the Caco-2 model of intestinal transport
Palika Datta, Margaret T Weis, Department of Biomedical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, United States
Author contributions: Weis MT designed the work; and Datta P performed the research.
Supported by AKPharma Corporation, MW.
Institutional review board statement: This study does not require Institutional Review Board approval.
Institutional animal care and use committee statement: No animals were used in this study.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Margaret T Weis, PhD, Associate Professor, Department of Biomedical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, TX 79106, United States. margaret.weis@ttuhsc.edu
Telephone: +1-806-4149215 Fax: +1-806-3564653
Received: March 13, 2015
Peer-review started: March 14, 2015
First decision: April 23, 2015
Revised: May 13, 2015
Accepted: June 26, 2015
Article in press: June 26, 2015
Published online: August 14, 2015
Processing time: 157 Days and 8.4 Hours
Peer-review started: March 14, 2015
First decision: April 23, 2015
Revised: May 13, 2015
Accepted: June 26, 2015
Article in press: June 26, 2015
Published online: August 14, 2015
Processing time: 157 Days and 8.4 Hours
Core Tip
Core tip: This article presents a novel role for calcium glycerophosphate in preserving the gut epithelial integrity during hypoxia and in the presence of cytokines. Calcium glycerophosphate showed a significant time and concentration dependent effect to attenuate increased gut permeability caused by hypoxia, cytokine stimulation and α-gliadin peptide 31-55. The effect was observable even at concentrations as low as 1 μmol/L. A better understanding of this phenomenon would help in devising new preventive and therapeutic regimens.