Expression of renal Oat5 and NaDC1 transporters in rats with acute biliary obstruction

doi:10.3748/wjg.v21.i29.8817

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Basic Study

World J Gastroenterol. Aug 7, 2015; 21(29): 8817-8825
Published online Aug 7, 2015. doi: 10.3748/wjg.v21.i29.8817

Expression of renal Oat5 and NaDC1 transporters in rats with acute biliary obstruction

Anabel Brandoni, Adriana Mónica Torres

Anabel Brandoni, Adriana Mónica Torres, Pharmacology, Department of Physiological Sciences, Faculty of Biochemical and Pharmaceutical Sciences, National University of Rosario, CONICET, Rosario 2000, Argentine

Author contributions: Brandoni A has designed research, performed research, contributed new reagents, analyzed data, wrote the paper; Torres AM has designed research, performed research, contributed new reagents, analyzed data, wrote the paper.

Supported by Grants from Fondo para la Investigación Científica y Tecnológica (FONCyT), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Rosario (UNR).

Institutional review board statement: The study was reviewed and approved by the National University of Rosario Institutional Review Board (Resol. C.S., No. 823/2013).

Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Faculty of Biochemical and Pharmaceutical Sciences-UNR (Resol., No, 637/2012).

Conflict-of-interest statement: Both authors have no conflict of interest.

Data sharing statement: No additional data are available.

Correspondence to: Adriana Mónica Torres, PhD, Professor of Pharmacology, Pharmacology, Department of Physiological Sciences, Faculty of Biochemical and Pharmaceutical Sciences, National University of Rosario, CONICET, Suipacha 531, Rosario 2000, Argentina. admotorres@yahoo.com.ar

Telephone: +54-341-4393400

Received: January 21, 2015
Peer-review started: January 29, 2015
First decision: June 2, 2015
Revised: June 18, 2015
Accepted: July 3, 2015
Article in press: July 3, 2015
Published online: August 7, 2015
Processing time: 198 Days and 18.1 Hours

Core Tip

Core tip: Organic anion transporter 5 (Oat5) is an organic anion/dicarboxylate exchanger which has impact on renal excretion of hormones, drugs and xenobiotics. The primary function of sodium-dicarboxylate cotransporter 1 (NaDC1) is to reabsorb filtered Krebs cycle intermediates, such as citrate. We found upregulations of both transporters and a decrease in urinary citrate excretion in bile duct-ligated rats. Citrate excretion is decreased at least in part, because of the higher NaDC1 expression. Using the outward gradient of citrate generated by NaDC1, Oat5 can reabsorb/eliminate different organic anions of pathophysiological importance. Attention might be paid for those drugs transported by this protein because their pharmacokinetics may be altered during cholestasis.