©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2015; 21(27): 8352-8357
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8352
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8352
Apoptosis of human pancreatic carcinoma cell-1 cells induced by Yin Chen Hao Decoction
Hai-Bo Zhou, Jing-Ming Chen, Li-Ming Shao, Zhi-Gang Chen, Department of Gastroenterology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China
Author contributions: Zhou HB designed and coordinated the research and wrote the paper; Chen JM and Chen ZG performed the majority of experiments; and Shao LM analyzed the data.
Supported by Traditional Chinese Medicine Administration of Zhejiang Province, China, No. 2014ZA068.
Institutional review board statement: The study was reviewed and approved by Chinese Medicine Administration Bureau of Zhejiang.
Conflict-of-interest statement: The authors declare no conflict of interests.
Data sharing statement: No additional data are available.
Correspondence to: Hai-Bo Zhou, MD, Department of Gastroenterology, the Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou 310009, Zhejiang Province, China. zhouhaibohz@163.com
Telephone: +86-571-87783564
Received: January 24, 2015
Peer-review started: January 25, 2015
First decision: February 10, 2015
Revised: March 9, 2015
Accepted: April 17, 2015
Article in press: April 17, 2015
Published online: July 21, 2015
Processing time: 178 Days and 19.7 Hours
Peer-review started: January 25, 2015
First decision: February 10, 2015
Revised: March 9, 2015
Accepted: April 17, 2015
Article in press: April 17, 2015
Published online: July 21, 2015
Processing time: 178 Days and 19.7 Hours
Core Tip
Core tip: Yin Chen Hao Decoction (YCHD) inhibits the growth of pancreatic carcinoma cells. Following treatment with YCHD for 24-96 h, the apoptotic rates in these cells is increased by YCHD, which is accompanied by time-dependent increased expression of Bax and decreased expression of Bcl-2. YCHD-induced apoptosis of these cells may be mediated by upregulation of BAX and downregulation of BCL-2.