©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2015; 21(24): 7362-7366
Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7362
Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7362
Immunomodulation of enteric neural function in irritable bowel syndrome
Dervla O’Malley, Department of Physiology and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
Author contributions: O’Malley D solely contributed to this paper.
Conflict-of-interest: The author has no financial, professional or personal conflicts relating to this publication.
Correspondence to: Dr. Dervla O’Malley, Department of Physiology and Alimentary Pharmabiotic Centre, University College Cork, 4.23 Western Gateway Building, Cork, Ireland. d.omalley@ucc.ie
Telephone: +353-21-4205483 Fax: +353-21-4205370
Received: January 7, 2015
Peer-review started: January 8, 2015
First decision: January 22, 2015
Revised: February 3, 2015
Accepted: March 12, 2015
Article in press: March 12, 2015
Published online: June 28, 2015
Processing time: 172 Days and 20.4 Hours
Peer-review started: January 8, 2015
First decision: January 22, 2015
Revised: February 3, 2015
Accepted: March 12, 2015
Article in press: March 12, 2015
Published online: June 28, 2015
Processing time: 172 Days and 20.4 Hours
Core Tip
Core tip: This article assesses the importance of neuroimmune modulation of gastrointestinal function in the functional bowel disorder, irritable bowel syndrome (IBS). Recent progress in understanding the molecular mechanisms underlying the pathophysiology of IBS reveals the neuromodulatory effects of mast cell mediators, cytokines and luminal microbiota.