Mazzarella G. Effector and suppressor T cells in celiac disease. World J Gastroenterol 2015; 21(24): 7349-7356 [PMID: 26139981 DOI: 10.3748/wjg.v21.i24.7349]
Corresponding Author of This Article
Giuseppe Mazzarella, DSC, Immuno-Morphology Lab, Institute of Food Sciences, National Council Research, Via Roma 64, 83100 Avellino, Italy. gmazzarella@isa.cnr.it
Research Domain of This Article
Immunology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jun 28, 2015; 21(24): 7349-7356 Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7349
Effector and suppressor T cells in celiac disease
Giuseppe Mazzarella
Giuseppe Mazzarella, Immuno-Morphology Lab, Institute of Food Sciences, National Council Research, 83100 Avellino, Italy
Author contributions: Mazzarella G solely contributed to this paper
Conflict-of-interest: I have no competing interests to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Giuseppe Mazzarella, DSC, Immuno-Morphology Lab, Institute of Food Sciences, National Council Research, Via Roma 64, 83100 Avellino, Italy. gmazzarella@isa.cnr.it
Telephone: +39-825-299391 Fax: +39-825-299104
Received: January 28, 2015 Peer-review started: January 29, 2015 First decision: March 10, 2015 Revised: April 9, 2015 Accepted: May 2, 2015 Article in press: May 4, 2015 Published online: June 28, 2015 Processing time: 151 Days and 16.6 Hours
Core Tip
Core tip: Although it is evident that effector gliadin-specific Th1 cells play an important role in celiac disease (CD) pathogenesis, recent studies have implicated Th17 effector cells in the disease process. Contrasting evidence has been reported on the ability of gliadin-specific cells to produce IL-17A. In addition, regulatory T cells, formerly known as suppressor T cells, have been identified in intestinal biopsy specimens of patients with active CD. Nevertheless, despite the presence of an endogenous counter-regulatory mechanism in the intestinal mucosa of celiac patients, the inflammatory response is not suppressed. In this review, we provide an overview of the current knowledge of the contribution of both Th1 and Th17 effector T cells and Treg cells in controlling mucosal inflammation in CD.
