Golovics PA, Lakatos L, Mandel MD, Lovasz BD, Vegh Z, Kurti Z, Szita I, Kiss LS, Pandur T, Lakatos PL. Prevalence and predictors of hospitalization in Crohn’s disease in a prospective population-based inception cohort from 2000-2012. World J Gastroenterol 2015; 21(23): 7272-7280 [PMID: 26109815 DOI: 10.3748/wjg.v21.i23.7272]
Corresponding Author of This Article
Peter L Lakatos, MD, PhD, First Department of Medicine, Semmelweis University, Koranyi S. 2/A, H-1083 Hungary. lakatos.peter_laszlo@med.semmelweis-univ.hu
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
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Golovics PA, Lakatos L, Mandel MD, Lovasz BD, Vegh Z, Kurti Z, Szita I, Kiss LS, Pandur T, Lakatos PL. Prevalence and predictors of hospitalization in Crohn’s disease in a prospective population-based inception cohort from 2000-2012. World J Gastroenterol 2015; 21(23): 7272-7280 [PMID: 26109815 DOI: 10.3748/wjg.v21.i23.7272]
World J Gastroenterol. Jun 21, 2015; 21(23): 7272-7280 Published online Jun 21, 2015. doi: 10.3748/wjg.v21.i23.7272
Prevalence and predictors of hospitalization in Crohn’s disease in a prospective population-based inception cohort from 2000-2012
Petra A Golovics, Laszlo Lakatos, Michael D Mandel, Barbara D Lovasz, Zsuzsanna Vegh, Zsuzsanna Kurti, Istvan Szita, Lajos S Kiss, Tunde Pandur, Peter L Lakatos
Petra A Golovics, Michael D Mandel, Barbara D Lovasz, Zsuzsanna Vegh, Zsuzsanna Kurti, Lajos S Kiss, Peter L Lakatos, First Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary
Laszlo Lakatos, Zsuzsanna Vegh, Istvan Szita, Tunde Pandur, Department of Medicine, Csolnoky Ferenc Province Hospital, H-8200 Veszprem, Hungary
Author contributions: Golovics PA and Lakatos L study design, data collection, supervising the collection and validation of patients, database construction, and manuscript preparation; Szita I and Pandur T data collection and manuscript preparation; Mandel MD, Lovasz BD, Vegh Z, Kurti Z and Kiss LS database construction, data validation, data analysis and manuscript preparation; Lakatos PL study design, data collection, supervising the collection and validation of patients, database construction, statistical analysis, and manuscript preparation; all authors have approved the final draft submitted.
Ethics approval: The study protocol was approved by Semmelweis University Regional and Institutional Committee of Science and Research Ethics and the Regional and Institutional Committee of Science and Research Ethics Veszprem.
Informed consent: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest: No potential conflicts of interest relevant to this article were reported.
Data sharing: No additional data are available.
Correspondence to: Peter L Lakatos, MD, PhD, First Department of Medicine, Semmelweis University, Koranyi S. 2/A, H-1083 Hungary. lakatos.peter_laszlo@med.semmelweis-univ.hu
Telephone: +36-1-2100278 Fax: +36-1-3130250
Received: January 5, 2015 Peer-review started: January 6, 2015 First decision: March 10, 2015 Revised: March 24, 2015 Accepted: May 4, 2015 Article in press: May 4, 2015 Published online: June 21, 2015 Processing time: 165 Days and 20.4 Hours
Core Tip
Core tip: Recent data on hospitalization rates in Crohn’s disease (CD) are lacking from population-based studies. In the present study our aim was to analyze the prevalence, cause and predictors of hospitalization and re-hospitalization in the population-based inception cohort from Veszprem province. Relatively high rates of CD-related hospitalizations and re-hospitalizations were found in our cohort, especially during the first year after the diagnosis. Non-inflammatory disease behavior at diagnosis, behavior change in patients with initial B1 behavior, perianal disease and total AZA and anti-TNF exposure was associated with the time to first CD-related hospitalization. Early CD-related hospitalization was associated with non-inflammatory disease behavior, perianal or internal fistulizing disease, need for immunosuppressives and need for surgeries during the disease course.
