Shen H, Yang J, Huang Q, Jiang MJ, Tan YN, Fu JF, Zhu LZ, Fang XF, Yuan Y. Different treatment strategies and molecular features between right-sided and left-sided colon cancers. World J Gastroenterol 2015; 21(21): 6470-6478 [PMID: 26074686 DOI: 10.3748/wjg.v21.i21.6470]
Corresponding Author of This Article
Ying Yuan, Professor, Department of Medical Oncology, 2nd Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. yuanying1999@zju.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Topic Highlight
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Shen H, Yang J, Huang Q, Jiang MJ, Tan YN, Fu JF, Zhu LZ, Fang XF, Yuan Y. Different treatment strategies and molecular features between right-sided and left-sided colon cancers. World J Gastroenterol 2015; 21(21): 6470-6478 [PMID: 26074686 DOI: 10.3748/wjg.v21.i21.6470]
Hong Shen, Jiao Yang, Qing Huang, Meng-Jie Jiang, Yi-Nuo Tan, Jian-Fei Fu, Li-Zhen Zhu, Xue-Feng Fang, Ying Yuan, Department of Medical Oncology, 2nd Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China
Author contributions: Shen H directed the study and drafted the manuscript; Yang J co- drafted the manuscript; Huang Q, Jiang MJ, Tan YN, Fu JF and Zhu LZ reviewed and edited the whole manuscript; Fang XF and Yuan Y designed the study, co-supervised field activities, and revised the manuscript critically for important intellectual content.
Supported by Grants from Key Projects in the National Science and Technology Pillar Program during the Twelfth Five-year Plan Period, No. 2014BAI09B07; and grants from the National Natural Science Foundation of China, No. 81101580 and No. 81201640.
Conflict-of-interest: All authors declare no conflicting interests, including but not limited to, commercial, personal, political, intellectual, or religious interests related to the article.
Correspondence to: Ying Yuan, Professor, Department of Medical Oncology, 2nd Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. yuanying1999@zju.edu.cn
Telephone: +86-571-87784795 Fax: +86-571-87767088
Received: January 27, 2015 Peer-review started: January 27, 2015 First decision: February 10, 2015 Revised: February 24, 2015 Accepted: March 31, 2015 Article in press: March 31, 2015 Published online: June 7, 2015 Processing time: 135 Days and 10 Hours
Core Tip
Core tip: The colon is derived from the embryological midgut and hindgut separately, with the right colon and left colon having different features with regards to anatomical and physiological characteristics. Based on the location, colon cancers are referred to as either right colon cancer (RCC) or left colon cancer (LCC), respectively, with both having distinct clinical manifestations. Increasing evidence supports the notion that differences exist in terms of sensitivity to adjuvant, palliative, and targeted treatments between RCC and LCC. In further analysis, significant varieties exist at the molecular level between RCC and LCC. Therefore, RCC and LCC should be regarded as two heterogeneous entities. Clinically, this heterogeneity is highly beneficial in therapeutic decision-making.
