Lai YH, Duan WD, Yu Q, Ye S, Xiao NJ, Zhang DX, Huang ZQ, Yang ZY, Dong JH. Outcomes of liver transplantation for end-stage biliary disease: A comparative study with end-stage liver disease. World J Gastroenterol 2015; 21(20): 6296-6303 [PMID: 26034365 DOI: 10.3748/wjg.v21.i20.6296]
Corresponding Author of This Article
Jia-Hong Dong, MD, PhD, FACS, Hospital and Institute of Hepatobiliary Surgery, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. dongjh301@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yan-Hua Lai, Wei-Dong Duan, Qiang Yu, Sheng Ye, Nian-Jun Xiao, Dong-Xin Zhang, Zhi-Qiang Huang, Jia-Hong Dong, Hospital and Institute of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China
Zhan-Yu Yang, Institute of Hepatobiliary Surgery, South West Hospital, Third Military Medical University, Chongqing 400038, China
Author contributions: Dong JH and Yang ZY proposed the study; Lai YH and Dong JH performed the research and wrote the first draft; all authors contributed to the design and interpretation of the study and to further drafts; Dong JH and Yang ZY are the guarantors.
Supported by National Science and Technology Major Project for Infectious Diseases of China, No. 2012ZX10002-017.
Ethics approval: The study was reviewed and approved by the Chinese PLA General Hospital Institutional Review Board.
Informed consent: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest: The authors declare that they have no conflicts of interest concerning this article.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jia-Hong Dong, MD, PhD, FACS, Hospital and Institute of Hepatobiliary Surgery, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. dongjh301@163.com
Telephone: +86-10-66938030 Fax: +86-10-68241383
Received: November 30, 2014 Peer-review started: November 30, 2014 First decision: January 8, 2015 Revised: February 7, 2015 Accepted: March 30, 2015 Article in press: March 31, 2015 Published online: May 28, 2015 Processing time: 180 Days and 17.5 Hours
Core Tip
Core tip: In this work, we evaluated the clinical characteristics of end-stage biliary disease (ESBD) and demonstrated that ESBD comprises a subset of disease that significantly differs from end-stage liver disease (ESLD), which is caused by hepatitis and cirrhosis. However, previous research on ESBD has been classified within the category of ESLD. The model for end-stage liver disease (MELD) does not adequately measure the clinical characteristics and stages of patients with ESBD before liver transplantation. Patients with ESBD would be less likely to receive priority for liver transplantation, and thus, the allocation system based on the MELD score is inappropriate and should be re-evaluated for patients with ESBD. In addition, the concept of ESBD and the indications for liver transplantation are established in this paper.
