Clinical Trials Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2015; 21(2): 616-622
Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.616
Copy number variations are progressively associated with the pathogenesis of colorectal cancer in ulcerative colitis
Bhadravathi Marigowda Shivakumar, Harish Rotti, Thanvanthri Gururajan Vasudevan, Aswath Balakrishnan, Sanjiban Chakrabarty, Ganesh Bhat, Lakshmi Rao, Cannanore Ganesh Pai, Kapaettu Satyamoorthy
Bhadravathi Marigowda Shivakumar, Department of Gastroenterology and Hepatology, Kasturba Medical College, Manipal University, Manipal 576104, India
Bhadravathi Marigowda Shivakumar, Harish Rotti, Thanvanthri Gururajan Vasudevan, Aswath Balakrishnan, Sanjiban Chakrabarty, Kapaettu Satyamoorthy, School of Life Sciences, Manipal University, Manipal 576104, India
Ganesh Bhat, Cannanore Ganesh Pai, Department of Gastroenterology and Hepatology, Kasturba Medical College, Manipal University, Manipal 576104, India
Lakshmi Rao, Department of Pathology, Kasturba Medical College, Manipal University, Manipal 576104, India
Author contributions: Satyamoorthy K and Pai CG conceived the project, along with Shivakumar BM designed the study, collected samples and clinical data; Shivakumar BM, Rotti H and Vasudevan TG were involved in carrying out molecular experiments, analyzing the data and drafting the manuscript; Balakrishnan A and Chakrabarty S were involved in data analysis and interpretation; Pai CG and Bhat G provided the samples; Rao L performed all pathological characterizations; Satyamoorthy K provided support for molecular analysis; all authors read and approved the final manuscript.
Supported by Grants from Department of Biotechnology (BT/01/COE/06/02/07) and TIFAC-CORE in Pharmacogenomics, Government of India.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Cannanore Ganesh Pai, Professor, Head, Department of Gastroenterology and Hepatology, Kasturba Medical College, Manipal University, Manipal, Karnataka 576104, India. cgpai@yahoo.co.in
Telephone: +91-820-2522385 Fax: +91-820-2571934
Received: March 11, 2014
Peer-review started: March 12, 2014
First decision: April 2, 2014
Revised: May 10, 2014
Accepted: July 22, 2014
Article in press: July 22, 2014
Published online: January 14, 2015
Processing time: 312 Days and 23.2 Hours
Core Tip

Core tip: Ulcerative colitis (UC) confers an increased risk of colorectal cancer (CRC). The role of copy number variations (CNVs) in different cancers including sporadic CRC has been established but their association in the development of colitis-associated neoplasia is not well described. Reports to date are limited to only a particular stage (e.g., dysplasia or cancer) in the development of colitis-associated cancer. In this first study of its kind, we report the association of increased numbers of known CNVs with the progression of UC to colitis-associated cancer.