©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2015; 21(2): 502-510
Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.502
Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.502
Hepatitis B virus infection, diabetes mellitus, and their synergism for cholangiocarcinoma development: A case-control study in Korea
Ban Seok Lee, Eun-Cheol Park, Seung Woo Park, Chung Mo Nam, Jaehoon Roh, Department of Medicine, Graduate School, Yonsei University College of Medicine, Seoul 120-752, South Korea
Ban Seok Lee, Digestive Disease Center and Department of Internal Medicine, Cheju Halla General Hospital, Jeju 690-766, South Korea
Eun-Cheol Park, Chung Mo Nam, Jaehoon Roh, Department of Preventive Medicine, Yonsei University College of Medicine, Seoul 120-752, South Korea
Eun-Cheol Park, Institute of Health Services Research, Yonsei University College of Medicine, Seoul 120-752, South Korea
Seung Woo Park, Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 120-752, South Korea
Author contributions: Roh J and Park EC contributed to the study concept and design; Lee BS and Nam CM contributed to the analysis and interpretation of data, and statistical analysis; Lee BS drafted the manuscript; Roh J, Park EC and Park SW performed critical revision of the manuscript for important intellectual content, and contributed to the study supervision.
Correspondence to: Jaehoon Roh, MD, PhD, Department of Preventive Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, South Korea. jhroh@yuhs.ac
Telephone: +82-2-22281867 Fax: +82-2-3928133
Received: June 6, 2014
Peer-review started: June 6, 2014
First decision: June 27, 2014
Revised: July 4, 2014
Accepted: July 30, 2014
Article in press: July 30, 2014
Published online: January 14, 2015
Processing time: 226 Days and 4 Hours
Peer-review started: June 6, 2014
First decision: June 27, 2014
Revised: July 4, 2014
Accepted: July 30, 2014
Article in press: July 30, 2014
Published online: January 14, 2015
Processing time: 226 Days and 4 Hours
Core Tip
Core tip: Although several risk factors for cholangiocarcinoma were identified in previous studies, details on their interactions or the influence of disease duration on the risk of cholangiocarcinoma are still unclear. Moreover, epidemiologic studies about cholangiocarcinoma in Korea are scarce. The present study in a Korean population showed that the impact of diabetes mellitus on the risk of cholangiocarcinoma was greater when diabetic complications were present. Further, it indicated that there was a synergistic effect between Hepatitis B virus infection and diabetes mellitus on the risk of cholangiocarcinoma, and that the synergistic effect was enhanced in cases of complicated diabetes.