©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2015; 21(2): 453-464
Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.453
Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.453
Aberrant EphB/ephrin-B expression in experimental gastric lesions and tumor cells
Shintaro Uchiyama, Noritaka Saeki, Kazushige Ogawa, Department of Veterinary Anatomy, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 598-8531, Japan
Author contributions: Ogawa K designed the experiments and wrote the paper; Uchiyama S and Ogawa K performed the experiments; Ogawa K, Uchiyama S, and Saeki N analyzed the data.
Supported by Grant-in-Aid for Scientific Research from Japan Society for the Promotion of Science, No. 21580367 (to Ogawa K).
Correspondence to: Kazushige Ogawa, DVM, PhD, Department of Veterinary Anatomy, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-Ourai-Kita, Izumisano, Osaka 598-8531, Japan. kogawa@vet.osakafu-u.ac.jp
Telephone: +81-72-4635584 Fax: +81-72-4635584
Received: March 27, 2014
Peer-review started: March 28, 2014
First decision: May 29, 2014
Revised: June 12, 2014
Accepted: July 22, 2014
Article in press: July 22, 2014
Published online: January 14, 2015
Processing time: 296 Days and 22.6 Hours
Peer-review started: March 28, 2014
First decision: May 29, 2014
Revised: June 12, 2014
Accepted: July 22, 2014
Article in press: July 22, 2014
Published online: January 14, 2015
Processing time: 296 Days and 22.6 Hours
Core Tip
Core tip: A constant/high level of EphB and ephrin-B coexpression was identified as a feature common to experimentally induced gastric dysplasia and human gastric carcinoma cell lines, as compared to normal and regenerating gastric epithelia. Based on these, we proposed that the stable/robust EphB and ephrin-B coexpression is a marker of dysplastic/oncogenic transformation. Eph signaling in tumor cells likely has a suppressive role during tumor progression, with Eph and ephrin coexpressed on the same cell engaging in non-productive interactions via lateral inhibition and thereby silencing downstream signaling. These results can be useful for the early and accurate diagnosis of gastric tumors.