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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2015; 21(19): 5877-5883
Published online May 21, 2015. doi: 10.3748/wjg.v21.i19.5877
Published online May 21, 2015. doi: 10.3748/wjg.v21.i19.5877
Effect of nuclear factor-κB and angiotensin II receptor type 1 on the pathogenesis of rat non-alcoholic fatty liver disease
Dao-Yu Tan, Department of Basic Nursing, The Nursing College of Luzhou Medical College, Luzhou 646000, Sichuan Province, China
Hai-Yan Shi, Department of Gastroenterology, People’s Hospital of Bazhong City, Bazhong 636600, Sichuan Province, China
Chang-Ping Li, Xiao-Ling Zhong, Ming Kang, Department of Gastroenterology, The Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China
Author contributions: Tan DY and Li CP designed the research; Shi HY performed the research; Zhong XL analyzed the data; all authors contributed to the writing and revising of the manuscript; Tan DY and Li CP contributed equally to the paper.
Supported by grants from the Science and Technology Department of Sichuan Province, No. 2011SZ0094.
Ethics approval: The study was reviewed and approved by the Affiliated Hospital of Luzhou Medical College Institutional Review Board.
Institutional animal care and use committee: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Affiliated Hospital of Luzhou Medical College (IACUC protocol number: [2012009]).
Conflict-of-interest: We declare that there is no conflict of interest to disclose.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Chang-Ping Li, Department of Gastroenterology, The Affiliated Hospital of Luzhou Medical College, No. 25 Taiping Street, Luzhou 646000, Sichuan Province, China. tandaoyu646@163.com
Telephone: +86 830 3161276 Fax: +86 830-2392753
Received: November 2, 2014
Peer-review started: November 2, 2014
First decision: December 2, 2014
Revised: January 17, 2015
Accepted: March 18, 2015
Article in press: March 19, 2015
Published online: May 21, 2015
Processing time: 198 Days and 20.3 Hours
Peer-review started: November 2, 2014
First decision: December 2, 2014
Revised: January 17, 2015
Accepted: March 18, 2015
Article in press: March 19, 2015
Published online: May 21, 2015
Processing time: 198 Days and 20.3 Hours
Core Tip
Core tip: Angiotensin II receptor type 1 (AT1R) is closely associated with the process of non-alcoholic fatty liver disease (NAFLD) fibrosis. As the nuclear transcription factor which is closely related to the tissue inflammation and fibrosis, when the activity of nuclear factor (NF)-κB was inhibited, AT1R mRNA expression was reduced, and the degrees of inflammation and fibrosis gradually reduced, indicating that NF-κB might play a key role throughout the course of NAFLD and that the NF-κB inhibitor might be effective in the treatment of the disease, while the exact mechanism still requires further study.