©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 7, 2015; 21(17): 5382-5392
Published online May 7, 2015. doi: 10.3748/wjg.v21.i17.5382
Published online May 7, 2015. doi: 10.3748/wjg.v21.i17.5382
Proton pump inhibitors in prevention of low-dose aspirin-associated upper gastrointestinal injuries
Chen Mo, Gang Sun, Ming-Liang Lu, Li Zhang, Yan-Zhi Wang, Xi Sun, Yun-Sheng Yang, Institute of Digestive Diseases, the Chinese PLA General Hospital, the Chinese PLA Medical Academy, Beijing 100853, China
Chen Mo, No. 2 Cadre Ward, the General Hospital of Armed Force Police, Beijing 100039, China
Author contributions: Mo C and Yang YS designed the research; Mo C, Lu ML, Zhang L and Wang YZ performed the research; Mo C, Sun G and Sun X analyzed the data; and Mo C wrote the paper.
Conflict-of-interest: The authors declare that they have no conflict-of-interest in this study.
Data sharing: No additional data are available.
Correspondence to: Yun-Sheng Yang, MD, PhD, Institute of Digestive Diseases, the Chinese PLA General Hospital, the Chinese PLA Medical Academy, Beijing 100853, China. sunny301ddc@126.com
Telephone: +86-10-55499005 Fax: +86-10-55499005
Received: September 26, 2014
Peer-review started: September 29, 2014
First decision: October 14, 2014
Revised: December 25, 2014
Accepted: January 30, 2015
Article in press: January 30, 2015
Published online: May 7, 2015
Processing time: 228 Days and 14 Hours
Peer-review started: September 29, 2014
First decision: October 14, 2014
Revised: December 25, 2014
Accepted: January 30, 2015
Article in press: January 30, 2015
Published online: May 7, 2015
Processing time: 228 Days and 14 Hours
Core Tip
Core tip: Ten randomized controlled trials on the preventive effect and safety of proton pump inhibitors (PPIs) in low-dose aspirin (LDA)-associated gastrointestinal tract injuries were included in this meta-analysis. Based on the data collected and presented, the authors conclude that PPIs are effective in preventing LDA-associated upper gastrointestinal tract ulcers and bleeding, without increasing the risk of major adverse cardiovascular events. The findings further confirm and extend the observations already published.