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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2015; 21(16): 4852-4863
Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4852
Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4852
Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction
Hai-Lian Shi, Chu-Hsuan Liu, Yu Zheng, Xiao-Yan Fei, Lu Lu, Jian-Ye Yuan, Jian-Qun Xie, Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Hai-Lian Shi, Li-Li Ding, Institute of Chinese Materia Medica, Shanghai Key Laboratory of Complex Prescription, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Xue-Ming Zhou, Experimental Animal Center, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Author contributions: Shi HL and Liu CH carried out all the experiments, analyzed the data and wrote the paper, and contributed equally to this study; Ding LL performed the HPLC analysis; Yuan JY and Xie JQ designed the experiments, analyzed the data, revised the paper, and contributed equally to this study; Zheng Y, Fei XY, Lu L and Zhou XM performed parts of the experiments and provided valuable suggestions for this study; all authors have read and approved the final manuscript.
Supported by Innovation Program of the Shanghai Municipal Education Commission, No. 12YZ065; National Natural Science Foundation of China, No. 81072786, No. 81473630 and No. 81202665; Longhua Medical Project, No. D-09; High level Project of the University of Educational Commission of Shanghai, China, No. 2008GSP19; and Shanghai Leading Academic Discipline Project, No. J50305.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jian-Ye Yuan, Associate Professor, Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 530 Lingling Road, Xuhui District, Shanghai 200032, China. yuanjianye@hotmail.com
Telephone: +86-21-64385700 Fax: +86-21-64398310
Received: September 22, 2014
Peer-review started: September 24, 2014
First decision: October 29, 2014
Revised: December 7, 2014
Accepted: January 30, 2015
Article in press: January 30, 2015
Published online: April 28, 2015
Processing time: 217 Days and 6.1 Hours
Peer-review started: September 24, 2014
First decision: October 29, 2014
Revised: December 7, 2014
Accepted: January 30, 2015
Article in press: January 30, 2015
Published online: April 28, 2015
Processing time: 217 Days and 6.1 Hours
Core Tip
Core tip: The present study demonstrated that Shugan decoction alleviated visceral hyperalgesia and attenuated colon motility in a rat model of irritable bowel syndrome, partly by regulating the expression of transient receptor potential (TRP) vanilloid 1, TRP vanilloid 4, TRP ankyrin-1 and protease-activated receptor 2, serotonin, chromogranin A and serotonin transporter, and reducing the levels of calcitonin-gene-related peptide and tumor necrosis factor-α.