Prospective Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2015; 21(14): 4310-4322
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4310
Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients
Kai Qu, Su-Shun Liu, Zhi-Xin Wang, Zi-Chao Huang, Si-Nan Liu, Hu-Lin Chang, Xin-Sen Xu, Ting Lin, Ya-Feng Dong, Chang Liu
Kai Qu, Su-Shun Liu, Zhi-Xin Wang, Zi-Chao Huang, Si-Nan Liu, Hu-Lin Chang, Xin-Sen Xu, Ting Lin, Chang Liu, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Ya-Feng Dong, Department of Obstetrics and Gynecology, University of Kansas School of Medicine, Kansas City, KS 66160, United States
Author contributions: Qu K and Liu C designed the research and wrote this paper; Liu SS, Wang ZX and Huang ZC performed the statistical analysis; Liu SN, Chang HL and Xu XS were involved in collecting patient data; Qu K and Lin T took part in literature searches; Dong YF edited the manuscript.
Supported by Grants from National Natural Science Foundation of China, No. 81201549 and No. 81272644; and the Project of Innovative Research Team for Key Science and Technology in Xi’an Jiaotong University, No. 2003KCJ-23.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chang Liu, MD, PhD, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an 710061, Shaanxi Province, China. liuchangdoctor@163.com
Telephone: +86-29-82654746 Fax: +86-29-82654746
Received: July 24, 2014
Peer-review started: July 24, 2014
First decision: August 10, 2014
Revised: August 19, 2014
Accepted: October 21, 2014
Article in press: October 21, 2014
Published online: April 14, 2015
Processing time: 265 Days and 7.2 Hours
Core Tip

Core tip: To determine the prognostic value of single nucleotide polymorphisms (SNPs) in GST genes in hepatocellular carcinoma (HCC) after liver resection, we analyzed the association between 12 tagging SNPs in GST genes and outcome of 214 HCC patients who underwent liver resection. Our data showed two SNPs (GSTO2: rs7085725 and GSTP1: rs4147581) to be significantly associated with overall survival in HCC patients. These two SNPs used in combination were more powerful prognostic markers for HCC patients. Our study provides the first evidence that GSTO2 and GSTP1 gene polymorphisms may serve as independent prognostic markers for HCC patients.