Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2015; 21(14): 4159-4168
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4159
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4159
Effects of Institut Georges Lopez-1 and Celsior preservation solutions on liver graft injury
Donia Tabka, Hassen Ben Abdennebi, Unité de recherche “Biologie et anthropologie moléculaire appliquées au développement et à la santé” (UR12ES11), University of Monastir, Faculty of Pharmacy, Monastir 5000, Tunisia
Mohamed Bejaoui, Joan Roselló-Catafau, Experimental Hepatic Ischemia-Reperfusion Unit, Institut d’Investigacions Biomèdiques de Barcelona-Consejo Superior de Investigaciones Cientificas, 08036 Barcelona, Spain
James Javellaud, Jean-Michel Achard, INSERM, Unité Mixte de Recherche S-850, 8000 Limoges, France
Author contributions: Tabka D and Bejaoui M performed the animal experiments, interpreted the data and wrote the article; Javellaud J did the teaching work and participated in the surgery required for the rat hepatic artery rings model; Roselló-Catafau J contributed to the critical revision of the article; Achard JM and Abdennebi HB designed the study and wrote the article; all the authors have read and approved the final manuscript.
Supported by Tunisian Ministry of Higher Education and Scientific Research, No.UR12ES11.
Institutional animal care and use committee: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Comité Regional D’Ethique pour L’Expérimentation Animale du Limousin (No.33).
Conflict-of-interest: There is no conflict of interest with any financial organization regarding the material discussed in the manuscript.
Data sharing: Technical appendix, statistical code and dataset are available from the corresponding author at (hbenabdennebi@yahoo.fr); all participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hassen Ben Abdennebi, Professor, Department of Physiology, Unité de Recherche “Biologie et anthropologie moléculaire appliquées au développement et à la santé” (UR12ES11), University of Monastir, Faculty of Pharmacy, Rue Avicenne, Monastir 5000, Tunisia. hbenabdennebi@yahoo.fr
Telephone: +216-73-461000
Received: November 6, 2014
Peer-review started: November 9, 2014
First decision: December 11, 2014
Revised: December 30, 2014
Accepted: January 30, 2015
Article in press: January 30, 2015
Published online: April 14, 2015
Processing time: 160 Days and 1.4 Hours
Peer-review started: November 9, 2014
First decision: December 11, 2014
Revised: December 30, 2014
Accepted: January 30, 2015
Article in press: January 30, 2015
Published online: April 14, 2015
Processing time: 160 Days and 1.4 Hours
Core Tip
Core tip: Vascular endothelium dysfunction plays an important role in various pathophysiological conditions. Protection of the vascular endothelium is a critical factor in organ preservation. This evaluation of the endothelium-dependent relaxation of rat hepatic artery after preservation in Celsior and Institut Georges Lopez (IGL-1) solutions provides the first head-to-head comparison of these two storage solutions. Our results show that cold storage of the hepatic artery with IGL-1 preserves nitric oxide-dependent endothelium-mediated relaxation better than cold storage with Celsior solution. In addition, we provide evidence that IGL-1 is more efficient than Celsior for liver preservation using an isolated perfused rat liver model.