Wang ZQ, Chen LQ, Yuan Y, Wang WP, Niu ZX, Yang YS, Cai J. Effects of neutrophil elastase inhibitor in patients undergoing esophagectomy: A systematic review and meta-analysis. World J Gastroenterol 2015; 21(12): 3720-3730 [PMID: 25834341 DOI: 10.3748/wjg.v21.i12.3720]
Corresponding Author of This Article
Long-Qi Chen, Professor, Department of Thoracic Surgery, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu 610041, Sichuan Province, China. drchenlq@gmail.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Mar 28, 2015; 21(12): 3720-3730 Published online Mar 28, 2015. doi: 10.3748/wjg.v21.i12.3720
Effects of neutrophil elastase inhibitor in patients undergoing esophagectomy: A systematic review and meta-analysis
Zhi-Qiang Wang, Long-Qi Chen, Yong Yuan, Wen-Ping Wang, Zhong-Xi Niu, Yu-Shang Yang, Jie Cai
Zhi-Qiang Wang, Long-Qi Chen, Yong Yuan, Wen-Ping Wang, Zhong-Xi Niu, Yu-Shang Yang, Jie Cai, Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Wang ZQ and Chen LQ designed the research; Wang ZQ, Chen LQ, Yuan Y and Wang WP performed the research; Chen LQ, Niu ZX and Yang YS analyzed the data; Wang ZQ, Chen LQ and Cai J wrote the paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Long-Qi Chen, Professor, Department of Thoracic Surgery, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu 610041, Sichuan Province, China. drchenlq@gmail.com
Telephone: +86-28-85421026 Fax: +86-28-85421026
Received: May 17, 2014 Peer-review started: May 17, 2014 First decision: June 10, 2014 Revised: June 23, 2014 Accepted: July 29, 2014 Article in press: July 30, 2014 Published online: March 28, 2015 Processing time: 317 Days and 3 Hours
Core Tip
Core tip: Radical esophagectomy has been adopted in patients with esophageal carcinoma to improve survival. This technique is highly invasive, leading to excess surgical stress, a perioperative mortality of 3%-10%, and pulmonary disorders account for nearly 30%-60%. Sivelestat sodium hydrate, a specific neutrophil elastase inhibitor, actively protects patients with acute respiratory diseases. The efficacy and safety of sivelestat administered during esophagectomy has produced conflicting results and the conclusions from relevant studies are presented. This meta-analysis revealed that sivelestat is beneficial in patients undergoing esophagectomy, especially in terms of the duration of mechanical ventilation and the incidence of pulmonary complications.
