Kim N, Yoo YC, Lee SK, Kim H, Ju HM, Min KT. Comparison of the efficacy and safety of sedation between dexmedetomidine-remifentanil and propofol-remifentanil during endoscopic submucosal dissection. World J Gastroenterol 2015; 21(12): 3671-3678 [PMID: 25834336 DOI: 10.3748/wjg.v21.i12.3671]
Corresponding Author of This Article
Kyeong Tae Min, MD, PhD, Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, South Korea. ktmin501@yuhs.ac
Research Domain of This Article
Anesthesiology
Article-Type of This Article
Randomized Controlled Trial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Kim N, Yoo YC, Lee SK, Kim H, Ju HM, Min KT. Comparison of the efficacy and safety of sedation between dexmedetomidine-remifentanil and propofol-remifentanil during endoscopic submucosal dissection. World J Gastroenterol 2015; 21(12): 3671-3678 [PMID: 25834336 DOI: 10.3748/wjg.v21.i12.3671]
World J Gastroenterol. Mar 28, 2015; 21(12): 3671-3678 Published online Mar 28, 2015. doi: 10.3748/wjg.v21.i12.3671
Comparison of the efficacy and safety of sedation between dexmedetomidine-remifentanil and propofol-remifentanil during endoscopic submucosal dissection
Namo Kim, Young-Chul Yoo, Sang Kil Lee, Hyunzu Kim, Hyang Mi Ju, Kyeong Tae Min
Namo Kim, Young-Chul Yoo, Hyunzu Kim, Hyang Mi Ju, Kyeong Tae Min, Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul 120-752, South Korea
Sang Kil Lee, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120-752, South Korea
Hyunzu Kim, Department of Anesthesiology and Pain Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul 134-701, South Korea
Author contributions: Kim N and Yoo YC contributed to conception and design, acquisition of data, or analysis and interpretation of data; Lee SK interpretation of data, revising the draft critically for important intellectual content; Kim H and Ju HM acquisition of data and analysis and interpretation of data; and Min KT substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data, and final approval of the version to be published.
Ethics approval: The study was reviewed and approved by the Institutional Review Board of Severance Hospital, Yonsei University Health System No. 4-2012-0621.
Clinical trial registration: This study is registered at http://ClinicalTrials.gov. The registration identification number is No. NCT01920113.
Informed consent: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest: The authors have no conflict-of-interest.
Data sharing: No additional data are available.
Correspondence to: Kyeong Tae Min, MD, PhD, Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, South Korea. ktmin501@yuhs.ac
Telephone: +82-2-22274161 Fax: +82-2-22277897
Received: September 12, 2014 Peer-review started: September 14, 2014 First decision: October 14, 2014 Revised: November 17, 2014 Accepted: January 8, 2015 Article in press: January 8, 2015 Published online: March 28, 2015 Processing time: 198 Days and 16.2 Hours
Core Tip
Core tip: Propofol and remifentanil are effectively used for endoscopic procedures. However, deep sedation especially with propofol is frequently associated with cardiorespiratory complications; therefore, it is of interest to identify shallower yet equally effective sedation protocols. Dexmedetomidine allows sedation without respiratory depression, and has also been utilized for sedation for endoscopic procedures. This study compared the efficacy and safety between propofol-remifentanil and dexmedetomidine-remifentanil during endoscopic submucosal dissection (ESD) from the perspective of the endoscopist and the patient. We found that efficacy and safety of dexmedetomidine-remifentanil were comparable to propofol-remifentanil during ESD, but the endoscopists favored the dexmedetomidine-remifentanil regimen perhaps due to lower gastric motility.
