Burock S, Herrmann P, Wendler I, Niederstrasser M, Wernecke KD, Stein U. Circulating metastasis associated in colon cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker. World J Gastroenterol 2015; 21(1): 333-341 [PMID: 25574109 DOI: 10.3748/wjg.v21.i1.333]
Corresponding Author of This Article
Ulrike Stein, Professor, Experimental and Clinical Research Center, Charité University Medicine Berlin and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin, Germany. ustein@mdc-berlin.de
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Gastroenterology & Hepatology
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research-article
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Burock S, Herrmann P, Wendler I, Niederstrasser M, Wernecke KD, Stein U. Circulating metastasis associated in colon cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker. World J Gastroenterol 2015; 21(1): 333-341 [PMID: 25574109 DOI: 10.3748/wjg.v21.i1.333]
World J Gastroenterol. Jan 7, 2015; 21(1): 333-341 Published online Jan 7, 2015. doi: 10.3748/wjg.v21.i1.333
Circulating metastasis associated in colon cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker
Ulrike Stein, Klaus-Dieter Wernecke, Markus Niederstrasser, Ina Wendler, Pia Herrmann, Susen Burock
Susen Burock, Charité Comprehensive Cancer Center, Invalidenstraße 80, 10117 Berlin, Germany
Pia Herrmann, Ulrike Stein, Experimental and Clinical Research Center, Charité University Medicine Berlin and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin, Germany
Ina Wendler, Markus Niederstrasser, Charité University Medicine Berlin, Lindenberger Weg 80, 13125 Berlin, Germany
Klaus-Dieter Wernecke, Institute of Medical Biometry, Charité University Medicine Berlin, Luisenstraße 65, 10117 Berlin, Germany
Author contributions: Burock S and Stein U designed the concept of the study; Herrmann P performed qRT-PCR; Burock S, Herrmann P, Wendler I and Stein U analyzed the data; Burock S, Niederstrasser M and Wernecke KD performed statistical analyses; Burock S and Stein U wrote the manuscript.
Correspondence to: Ulrike Stein, Professor, Experimental and Clinical Research Center, Charité University Medicine Berlin and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin, Germany. ustein@mdc-berlin.de
Telephone: +49-30-94063432 Fax: +49-30-94062780
Received: March 21, 2014 Peer-review started: March 23, 2014 First decision: April 2, 2014 Revised: May 5, 2014 Accepted: July 22, 2014 Article in press: July 22, 2014 Published online: January 7, 2015 Processing time: 291 Days and 17.6 Hours
Core Tip
Core tip: We provide for the first time a blood-based assay for transcript quantification of the metastasis inducer Metastasis Associated in Colon Cancer 1 (MACC1) in a prospective study of gastric cancer patients. MACC1 is a strong prognostic biomarker for tumor progression and metastasis in a variety of solid cancers. We discriminated tumor-free volunteers and gastric cancer patients (all P < 0.001, sensitivity 0.68 (95%CI: 0.45-0.85), specificity 0.89 (95%CI: 0.77-0.95) of each disease stage (P < 0.05 for each). Shorter survival correlated with high circulating MACC1 transcript levels (P = 0.0015). Thus, circulating MACC1 transcript levels in plasma of gastric cancer patients are of diagnostic value and are prognostic for patient survival.
