Topic Highlight
Copyright ©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Feb 21, 2014; 20(7): 1681-1693
Published online Feb 21, 2014. doi: 10.3748/wjg.v20.i7.1681
CXC chemokines and chemokine receptors in gastric cancer: From basic findings towards therapeutic targeting
Hyo Jin Lee, Ik-Chan Song, Hwan-Jung Yun, Deog-Yeon Jo, Samyong Kim
Hyo Jin Lee, Hwan-Jung Yun, Deog-Yeon Jo, Samyong Kim, Division of Hematology/Oncology, Department of Internal Medicine, School of Medicine Chungnam National University and Chungnam National University Hospital, Daejeon 301-721, South Korea
Hyo Jin Lee, Hwan-Jung Yun, Deog-Yeon Jo, Samyong Kim, Cancer Research Institute, Chungnam National University, Daejeon 301-721, South Korea
Ik-Chan Song, Division of Hematology/Oncology, Department of Internal Medicine, Chungnam National University Hospital, Daejeon 301-721, South Korea
Author contributions: Lee HJ, Song IC, Yun HJ, Jo DY and Kim S conceived the study and coordinated literature data; Lee HJ and Jo DY drafted, reviewed and approved the manuscript.
Supported by Basic Science Research Program through the National Research of Korea (NRF) funded by the Ministry of Education, Science and Technology, NRF-2009-0076540, NRF-2009-0067256
Correspondence to: Deog-Yeon Jo, MD, PhD, Division of Hematology/Oncology, Department of Internal Medicine, School of Medicine Chungnam National University and Chungnam National University Hospital, 640 Daesa-dong, Jung-gu, Daejeon 301-721, South Korea. ggufwhd@naver.com
Telephone: +82-42-2807162 Fax: +82-42-2575753
Received: August 23, 2013
Revised: October 1, 2013
Accepted: November 12, 2013
Published online: February 21, 2014
Processing time: 201 Days and 11.3 Hours
Core Tip

Core tip: Chemokines were traditionally believed to regulate the directional migration of leukocytes to inflammatory sites. However, it is now clear that chemokines and chemokine receptors also regulate the processes underlying the development and progression of malignant disease. In gastric cancer, CXC chemokines and their receptors directly influence tumorigenesis by modulating tumor transformation, survival, growth, invasion, and metastasis, as well as indirectly by regulating angiogenesis and interactions between tumor and microenvironment. Aim of this review is to discuss the involvement of CXC chemokines and their receptors in the development, progression, and metastasis of gastric cancer and their therapeutic potential.