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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 28, 2014; 20(48): 18338-18345
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18338
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18338
Comparative study of mutations in SNP loci of K-RAS, hMLH1 and hMSH2 genes in neoplastic intestinal polyps and colorectal cancer
Zhi-Hui Yan, Li-Hong Cui, Xiao-Hui Wang, Chao Li, Xing He, Department of Gastroenterology, Navy General Hospital of PLA, Beijing 100048, China
Author contributions: Yan ZH and Cui LH contributed equally to this work; all authors contributed to the manuscript.
Supported by Capital Public Health Project Cultivation Program, No. Z111107067311051
Correspondence to: Li-Hong Cui, PhD,MD, Department of Gastroenterology, Navy General Hospital of PLA, 6 Fucheng Road, Beijing 100048, China. luckycui861@sina.com
Telephone: +86-10-66957541 Fax: +86-10-68780570
Received: June 8, 2014
Revised: July 12, 2014
Accepted: August 13, 2014
Published online: December 28, 2014
Processing time: 211 Days and 21.2 Hours
Revised: July 12, 2014
Accepted: August 13, 2014
Published online: December 28, 2014
Processing time: 211 Days and 21.2 Hours
Core Tip
Core tip: This study selects the blood and tissue samples of neoplastic polyps, colorectal cancer and normal tissues for related gene sequencing. By comparing the differences in SNPs, the genetics and pathogenesis of colorectal cancer are analyzed.