Wang XC, Zhan XR, Li XY, Yu JJ, Liu XM. MicroRNA-185 regulates expression of lipid metabolism genes and improves insulin sensitivity in mice with non-alcoholic fatty liver disease. World J Gastroenterol 2014; 20(47): 17914-17923 [PMID: 25548489 DOI: 10.3748/wjg.v20.i47.17914]
Corresponding Author of This Article
Xiao-Min Liu, MD, Professor, Department of Endocrinology, First Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang Province, China. liuxiaomin2013a@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Original Article
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World J Gastroenterol. Dec 21, 2014; 20(47): 17914-17923 Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17914
MicroRNA-185 regulates expression of lipid metabolism genes and improves insulin sensitivity in mice with non-alcoholic fatty liver disease
Xiao-Chen Wang, Xiao-Rong Zhan, Xin-Yu Li, Jun-Jie Yu, Xiao-Min Liu
Xiao-Chen Wang, Xiao-Rong Zhan, Xin-Yu Li, Jun-Jie Yu, Xiao-Min Liu, Department of Endocrinology, First Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Author contributions: Zhan XR and Liu XM designed the research; Wang XC, Li XY and Yu JJ performed the research; Wang XC and Li XY analyzed the data; Wang XC wrote the paper.
Supported by National Natural Science Foundation of China, No. 30950005; and the Department of Education of Heilongjiang Province, No. 12511233
Correspondence to: Xiao-Min Liu, MD, Professor, Department of Endocrinology, First Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang Province, China. liuxiaomin2013a@163.com
Telephone: +86-13804591081 Fax: +86-451-85555928
Received: May 24, 2014 Revised: August 16, 2014 Accepted: September 18, 2014 Published online: December 21, 2014 Processing time: 210 Days and 8.4 Hours
Core Tip
Core tip: Our study presents important information on the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and insulin resistance. We used a bioinformatics method to identify microRNAs potentially involved in the regulation of lipid metabolism and insulin signalling. We chose microRNA-185 (miR-185) to validate in vitro and in vivo in regard to regulation of lipid metabolism gene expression and blockade of the insulin signalling pathway. We found that overexpression of miR-185 improved insulin sensitivity and reduced liver steatosis in an NAFLD animal model. No previous studies have reported the regulatory effect of miR-185 on the insulin signalling pathway. MiR-185 might be useful in the design of therapeutic strategies for treating NAFLD and insulin resistance.
