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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2014; 20(47): 17796-17803
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17796
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17796
Molecular diagnosis and therapy for occult peritoneal metastasis in gastric cancer patients
Shunsuke Kagawa, Kunitoshi Shigeyasu, Michihiro Ishida, Megumi Watanabe, Hiroshi Tazawa, Takeshi Nagasaka, Yasuhiro Shirakawa, Toshiyoshi Fujiwara, Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
Author contributions: Kagawa S wrote the manuscript; Shigeyasu K, Ishida M, Watanabe M and Tazawa H contributed to review and interpretation of the literatures; Nagasaka T, Shirakawa Y and Fujiwara T supervised the review; all authors have read and approved the final version to be published.
Supported by Grants from Ministry of Education, Science, and Culture, Japan (to Kagawa S) and JSPS KAKENHI, No. 23591932
Correspondence to: Shunsuke Kagawa, MD, PhD, Associate Professor, Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. skagawa@md.okayama-u.ac.jp
Telephone: +81-86-2357257 Fax: +81-86-2218775
Received: April 16, 2014
Revised: June 7, 2014
Accepted: June 25, 2014
Published online: December 21, 2014
Processing time: 248 Days and 8.2 Hours
Revised: June 7, 2014
Accepted: June 25, 2014
Published online: December 21, 2014
Processing time: 248 Days and 8.2 Hours
Core Tip
Core tip: For patients with gastric cancer, cytological detection of cancer cells in the peritoneal cavity is important to predict future manifestation of peritoneal recurrence. However, its improvement has been a matter of research, because of its low sensitivity and specificity. The new diagnostic modalities have been investigated along with the development of modern molecular biology. The recent innovative challenges regarding molecular diagnosis of intra-peritoneal gastric cancer cells have been thoroughly covered and summarized. The new therapies for gastric cancer with peritoneal spreads were also referred.