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World J Gastroenterol. Nov 21, 2014; 20(43): 15975-15991
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.15975
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.15975
Impact of lipids and lipoproteins on hepatitis C virus infection and virus neutralization
Koen Vercauteren, Ahmed Atef Mesalam, Geert Leroux-Roels, Philip Meuleman, Center for Vaccinology, Ghent University Hospital, Ghent University, B-9000 Ghent, Belgium
Author contributions: Vercauteren K and Mesalam AA wrote the paper; Leroux-Roels G and Meuleman P critically revised it.
Supported by Ghent University, Grants No. 01G00507 and No. 01G01712; Research Foundation - Flanders, Projects No. 1500910N, No. G0212.10N and No. G052112N (FWO-Vlaanderen); Belgian Federal Government, No. IUAP P6/36-HEPRO and No. P7/47-HEPRO-2; and European Union No. FP6 HEPACIVAC; FP7, HepaMab; Mesalam AA is a recipient of a PhD Fellowship provided by the Egyptian government
Correspondence to: Philip Meuleman, Professor, Center for Vaccinology, Ghent University Hospital, Ghent University, Building A, 1st floor, De Pintelaan 185, B-9000 Gent, Belgium. philip.meuleman@ugent.be
Telephone: +32-9-3323658 Fax: +32-9-3326311
Received: May 28, 2014
Revised: July 9, 2014
Accepted: September 5, 2014
Published online: November 21, 2014
Processing time: 175 Days and 21.8 Hours
Revised: July 9, 2014
Accepted: September 5, 2014
Published online: November 21, 2014
Processing time: 175 Days and 21.8 Hours
Core Tip
Core tip: We reviewed the influence of lipids and lipoproteins on the hepatitis C virus life cycle and their impact on viral neutralization by antibodies that target the viral envelope proteins or that target the receptors used by the virus to infect the hepatocyte.