Copyright
©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 14, 2014; 20(42): 15899-15909
Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15899
Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15899
Interleukin-17 SNPs and serum levels increase ulcerative colitis risk: A meta-analysis
Juan Li, Department of Gastroenterology, the Third Affiliated Hospital of Liaoning Medical University, Jinzhou 120000, Liaoning Province, China
Hao Tian, Hui-Jun Jiang, Bin Han, Department of Infectious Diseases, the First Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China
Author contributions: Han B conceived of and designed the experiments; Li J and Tian H performed the experiments; Li J analyzed the data; Jiang HJ contributed materials and analysis tools; Li J wrote the manuscript; Han B reviewed and modified the manuscript.
Correspondence to: Bin Han, PhD, Professor, Department of Infectious Diseases, The First Affiliated Hospital of Liaoning Medical University, Renmin Street, Section 5, No. 2, Guta District, Jinzhou 121000, Liaoning Province, China. lnmu3h_hb@sina.com
Telephone: +86-416-3999373 Fax: +86-416-3999373
Received: November 8, 2013
Revised: April 5, 2014
Accepted: June 12, 2014
Published online: November 14, 2014
Processing time: 374 Days and 2.6 Hours
Revised: April 5, 2014
Accepted: June 12, 2014
Published online: November 14, 2014
Processing time: 374 Days and 2.6 Hours
Core Tip
Core tip: This is the first meta-analysis focusing on the associations of interleukin-17 (IL-17) genetic polymorphisms and serum IL-17 levels with the risk of ulcerative colitis. The results of the study indicate that both IL-17A/F genetic polymorphisms and serum IL-17 levels may play a role in the development and progression of ulcerative colitis.