Elevated miR-33a and miR-224 in steatotic chronic hepatitis C liver biopsies

doi:10.3748/wjg.v20.i41.15343

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 7, 2014; 20(41): 15343-15350
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15343

Elevated miR-33a and miR-224 in steatotic chronic hepatitis C liver biopsies

Gabor Lendvai, Katalin Jármay, Gizella Karácsony, Tünde Halász, Ilona Kovalszky, Kornélia Baghy, Tibor Wittmann, Zsuzsa Schaff, András Kiss

Gabor Lendvai, Zsuzsa Schaff, MTA-SE Tumor Progression Research Group, Semmelweis University, 1091 Budapest, Hungary

Katalin Jármay, Gizella Karácsony, Tibor Wittmann, 1^st Department of Medicine, University of Szeged, 6720 Szeged, Hungary

Tünde Halász, Zsuzsa Schaff, András Kiss, 2^nd Department of Pathology, Semmelweis University, 1091 Budapest, Hungary

Ilona Kovalszky, Kornélia Baghy, 1^st Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary

Author contributions: Jármay K, Schaff Z and Kiss A designed the study; Jármay K, Karácsony G, Kovalszky I, Wittmann T, Schaff Z and Kiss A chose and diagnosed the patient samples; Lendvai G, Karácsony G and Halász T performed the research; Lendvai G, Jármay K, Karácsony G, Kovalszky I, Baghy K, Schaff Z and Kiss A analyzed and interpreted the data; Lendvai G, Schaff Z and Kiss A wrote the paper; all authors critically reviewed and approved the manuscript.

Supported by Grants from the National Scientific Research Fund, No. OTKA K101435, No. K108548 and No. 105763

Correspondence to: Zsuzsa Schaff, MD, PhD, DSc, Professor of Pathology, 2^nd Department of Pathology, Semmelweis University, Ulloi 93, 1091 Budapest, Hungary. schaff.zsuzsa@med.semmelweis-univ.hu

Telephone: +36-1-215-6921 Fax: +36-1-215-6921

Received: February 11, 2014
Revised: May 7, 2014
Accepted: June 13, 2014
Published online: November 7, 2014
Processing time: 271 Days and 23.6 Hours

Core Tip

Core tip: Chronic hepatitis C (CHC) and steatosis are liver diseases that can progress into hepatocellular carcinoma. In the current study, differences were found in expression of selected microRNAs in biopsy samples of steatotic liver, CHC-infected, and steatotic CHC-infected liver, compared to control samples. Interestingly, levels of miR-224, which are increased in hepatocellular carcinoma, were elevated in both types of steatotic liver when compared with normal or CHC-infected only liver tissues, and may be an indicator of a precancerous state.