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World J Gastroenterol. Jan 28, 2014; 20(4): 1054-1060
Published online Jan 28, 2014. doi: 10.3748/wjg.v20.i4.1054
Published online Jan 28, 2014. doi: 10.3748/wjg.v20.i4.1054
Intra-gastric triacetin alters upper gastrointestinal motility in conscious dogs
Kazumasa Oosaka, Research and Development Department, Fushimi Pharmaceutical Co., Ltd., Kagawa 7638605, Japan
Masaaki Tokuda, Department of Cell Physiology, Faculty of Medicine, Kagawa University, Kagawa 7610793, Japan
Naohiro Furukawa, Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki 7010193, Japan
Author contributions: Oosaka K and Furukawa N contributed equally in performing the research, analyzing the data, and writing the manuscript; and Tokuda M contributed to the design of the research project.
Correspondence to: Dr. Kazumasa Oosaka, Research and Development Department, Fushimi Pharmaceutical Co., Ltd., Nakatsu-cho 1676, Marugame, Kagawa 7638605, Japan. ohsaka@fushimi.co.jp
Telephone: +81-877-226272 Fax: +81-877-226246
Received: August 31, 2013
Revised: October 30, 2013
Accepted: December 5, 2013
Published online: January 28, 2014
Processing time: 148 Days and 15.5 Hours
Revised: October 30, 2013
Accepted: December 5, 2013
Published online: January 28, 2014
Processing time: 148 Days and 15.5 Hours
Core Tip
Core tip: Intra-gastric infusion of short-chain triglycerides, such as triacetin, has been shown to delay gastric emptying in conscious dogs, but the influence on upper gastrointestinal motility is unknown. The current study examined time-dependent changes in motility following intra-gastric triacetin administration at various doses in conscious dogs and evaluated the effects of a fasted vs fed state. Compared to infusion of water (vehicle) alone, the 1.0% and 2.0% triacetin doses induced a significant increase in the proximal stomach receptive volume, a temporary inhibition of gastric antral contractions, and an increase in the duodenal contractions in fasted dogs.