Copyright
©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2014; 20(39): 14420-14429
Published online Oct 21, 2014. doi: 10.3748/wjg.v20.i39.14420
Published online Oct 21, 2014. doi: 10.3748/wjg.v20.i39.14420
Production of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine
Shigeo Koido, Toshifumi Ohkusa, Kazuki Takakura, Keisuke Saito, Zensho Ito, Hiroko Kobayashi, Shinichiro Takami, Kan Uchiyama, Hiroshi Arakawa, Mikio Kajihara, Hisao Tajiri, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Chiba 277-8567, Japan
Shin Kan, Hideo Komita, Masaki Ito, Sadamu Homma, Department of Oncology, The Jikei University School of Medicine, Tokyo 105-8461, Japan
Masato Okamoto, Department of Advanced Immunotherapeutics, Kitasato University School of Pharmacy, Tokyo 108-8641, Japan
Author contributions: Koido S, Ohkusa T and Tajiri H designed the research; Koido S, Kan S, Takakura K, Saito K, Komita H, Ito Z, Kobayashi H, Takami S, Uchiyama K, Arakawa H, Ito M, Okamoto M, Kajihara M and Homma S performed the research and analyzed the data; Koido S wrote the paper.
Supported by Grants-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and the Foundation for the Promotion of Cancer Research and Mitsui Life Social Welfare Foundation
Correspondence to: Shigeo Koido, MD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, 163-1 Kashiwa-shita, Kashiwa, Chiba 277-8564, Japan. shigeo_koido@jikei.ac.jp
Telephone: +81-4-71641111 Fax: +81-4-71633488
Received: February 22, 2014
Revised: April 17, 2014
Accepted: May 25, 2014
Published online: October 21, 2014
Processing time: 240 Days and 10.1 Hours
Revised: April 17, 2014
Accepted: May 25, 2014
Published online: October 21, 2014
Processing time: 240 Days and 10.1 Hours
Core Tip
Core tip: Corticotropin-releasing factor (CRF) and urocortin 1 (UCN1) play critical roles in many stress-related intestinal disorders, such as irritable bowel syndrome and inflammatory bowel disease. However, little is known about the pathophysiology of these diseases. To examine whether commensal bacteria are a contributing cause of stress-related mucosal inflammation, human peripheral blood monocyte-derived dendritic cells were stimulated by commensal bacterial strains. Both CRF and UCN1 were significantly augmented by Bacteroides vulgatus (B. vulgatus) and Fusobacterium varium (F. varium) at both the mRNA and protein levels. Thus, B. vulgatus and F. varium may be associated with stress-related intestinal disorders.