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World J Gastroenterol. Oct 14, 2014; 20(38): 13911-13919
Published online Oct 14, 2014. doi: 10.3748/wjg.v20.i38.13911
Published online Oct 14, 2014. doi: 10.3748/wjg.v20.i38.13911
Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice (ob/ob)
Márcia Sanae Mizuno, Patricia Castelucci, Department of Anatomy/Biomedical Science Institute, University of São Paulo, São Paulo 05508-900, Brazil
Amanda Rabello Crisma, Primavera Borelli, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-900, Brazil
Bárbara Tavares Schäfer, Mariana Póvoa Silveira, Department of Surgery, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-900, Brazil
Author contributions: Mizuno MS performed all of the experiments and analyzed the results for this work; Crisma AR and Borelli P collected and analyzed the blood samples; Schäfer BT and Silveira MP helped write and edit the manuscript; Castelucci P planned the study and wrote the manuscript.
Supported by São Paulo Research Foundation (FAPESP/São Paulo Research Foundation/Proc: 05/04752-0) and CAPES Fellowship
Correspondence to: Patricia Castelucci, PhD, Department of Anatomy/Biomedical Science Institute, University of São Paulo, R. Dr. Lineu Prestes 2415, São Paulo 05508-900, Brazil. pcastel@usp.br
Telephone: +55-11-30918463 Fax: +55-11-30917366
Received: February 10, 2014
Revised: April 29, 2014
Accepted: June 13, 2014
Published online: October 14, 2014
Processing time: 247 Days and 16.4 Hours
Revised: April 29, 2014
Accepted: June 13, 2014
Published online: October 14, 2014
Processing time: 247 Days and 16.4 Hours
Core Tip
Core tip: The neuronal density (neuron/cm2) of nitric oxide synthase- and calretinin-ir neurons are decreased and the density of choline acetyl transferase-ir neurons is significantly increased in male ob/ob mice. In addition, the P2X2 receptor is only expressed in the enteric neurons of healthy mice. These findings have clinical relevance for understanding alterations in gastrointestinal motility in obesity.