Vasuri F, Malvi D, Rosini F, Baldin P, Fiorentino M, Paccapelo A, Ercolani G, Pinna AD, Golfieri R, Morselli-Labate AM, Grigioni WF, D’Errico-Grigioni A. Revisiting the role of pathological analysis in transarterial chemoembolization-treated hepatocellular carcinoma after transplantation. World J Gastroenterol 2014; 20(37): 13538-13545 [PMID: 25309084 DOI: 10.3748/wjg.v20.i37.13538]
Corresponding Author of This Article
Antonia D’Errico-Grigioni, MD, “F. Addarii” Institute of Oncology and Transplantation Pathology, S.Orsola-Malpighi Hospital, Bologna University, V.le Ercolani 4/2, 40138 Bologna, Italy. derrico@aosp.bo.it
Research Domain of This Article
Pathology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Vasuri F, Malvi D, Rosini F, Baldin P, Fiorentino M, Paccapelo A, Ercolani G, Pinna AD, Golfieri R, Morselli-Labate AM, Grigioni WF, D’Errico-Grigioni A. Revisiting the role of pathological analysis in transarterial chemoembolization-treated hepatocellular carcinoma after transplantation. World J Gastroenterol 2014; 20(37): 13538-13545 [PMID: 25309084 DOI: 10.3748/wjg.v20.i37.13538]
World J Gastroenterol. Oct 7, 2014; 20(37): 13538-13545 Published online Oct 7, 2014. doi: 10.3748/wjg.v20.i37.13538
Revisiting the role of pathological analysis in transarterial chemoembolization-treated hepatocellular carcinoma after transplantation
Antonia D’Errico-Grigioni, Walter Franco Grigioni, Antonio Maria Morselli-Labate, Rita Golfieri, Antonio Daniele Pinna, Giorgio Ercolani, Alexandro Paccapelo, Michelangelo Fiorentino, Pamela Baldin, Francesca Rosini, Deborah Malvi, Francesco Vasuri
Francesco Vasuri, Deborah Malvi, Francesca Rosini, Pamela Baldin, Michelangelo Fiorentino, Walter Franco Grigioni, Antonia D’Errico-Grigioni, “F. Addarii” Institute of Oncology and Transplantation Pathology, S.Orsola-Malpighi Hospital, Bologna University, 40138 Bologna, Italy
Alexandro Paccapelo, Antonio Maria Morselli-Labate, Department of Medical and Surgical Sciences, Bologna University, 40138 Bologna, Italy
Giorgio Ercolani, Antonio Daniele Pinna, Department of Surgery and Transplantation, S.Orsola-Malpighi Hospital, Bologna University, 40138 Bologna, Italy
Rita Golfieri, Radiology Unit, S. Orsola-Malpighi Hospital, Bologna University, 40138 Bologna, Italy
Author contributions: Vasuri F designed and performed the research, revised the histology, collected and analyzed data, wrote the manuscript; Malvi D performed the research, revised the histology, wrote the manuscript; Rosini F, Baldin P and Fiorentino M revised the histology and collected pathological data; Paccapelo A and Morselli-Labate AM performed the statistical analysis and calculate the histological score; Ercolani G and Pinna AD collected clinical data and critically reviewed the manuscript; Golfieri R and Grigioni WF analyzed data and critically reviewed the manuscript; D’Errico-Grigioni A designed the research and critically reviewed the manuscript.
Correspondence to: Antonia D’Errico-Grigioni, MD, “F. Addarii” Institute of Oncology and Transplantation Pathology, S.Orsola-Malpighi Hospital, Bologna University, V.le Ercolani 4/2, 40138 Bologna, Italy. derrico@aosp.bo.it
Telephone: +39-51-6364546 Fax: +39-51-6364403
Received: February 16, 2014 Revised: April 18, 2014 Accepted: May 25, 2014 Published online: October 7, 2014 Processing time: 232 Days and 21.5 Hours
Core Tip
Core tip: Transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC) is used for down-staging before orthotopic liver transplantation (OLT), and as “bridging therapy” to reduce the drop-out rates in the waiting list. A discrepancy exists between the pre-transplant (radiological) and post-transplant (pathological) staging. Few study analyzing the histology of TACE-treated HCC exist. Here we analyzed 11 histological variables in 275 nodules from 101 consecutive OLT recipients and we computed a histological score to stratify recipients into 3 risk groups, with 3.3%, 18.5% and 53.8% respectively of tumor recurrence rates. The histological score allows a better stratification of those recipients beyond the Milan criteria after OLT.
