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World J Gastroenterol. Sep 28, 2014; 20(36): 12900-12907
Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.12900
Postoperative adjuvant chemoradiotherapy in D2-dissected gastric cancer: Is radiotherapy necessary after D2-dissection?
Jee Suk Chang, Woong Sub Koom, Youngin Lee, Hong In Yoon, Hyung Sik Lee
Jee Suk Chang, Woong Sub Koom, Youngin Lee, Hong In Yoon, Department of Radiation Oncology, Yonsei University College of Medicine, Seoul 120-752, South Korea
Hyung Sik Lee, Department of Radiation Oncology, Dong-A University Hospital, Busan 602-715, South Korea
Author contributions: Chang JS and Koom WS contributed equally to this work as first authors; Koom WS and Lee HS designed the research; Chang JS, Koom WS, Lee Y, Yoon HI and Lee HS performed the research; Chang JS, Koom WS, Lee Y, Yoon HI and Lee HS analyzed the data; Chang JS, Koom WS, Lee Y and Lee HS wrote the paper.
Correspondence to: Hyung Sik Lee, MD, Department of Radiation Oncology, Dong-A University Hospital, 1-3 Dongdaesindong, Seo-gu, Busan 602-715, South Korea. hyslee@dau.ac.kr
Telephone: +82-51-2405380 Fax: +82-51-2402135
Received: October 28, 2013
Revised: January 24, 2014
Accepted: April 5, 2014
Published online: September 28, 2014
Processing time: 338 Days and 7.2 Hours
Core Tip

Core tip: The survival benefits of postoperative chemoradiotherapy (CRT) in gastric cancer with D0/1-dissection have been established in Western countries. However, in Eastern areas, where D2-dissection is the standard surgical procedure, most surgeons are skeptical about the benefit of CRT in D2-dissected patients, and CRT has not been examined in this setting in clinical trials. Here we aimed to provide a review of recent research and to suggest future directions regarding adjuvant CRT after D2-dissection.