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World J Gastroenterol. Sep 14, 2014; 20(34): 11950-11961
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.11950
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.11950
Extraintestinal manifestations of Helicobacter pylori: A concise review
Frank Wong, Erin Rayner-Hartley, Michael F Byrne, Division of Gastroenterology, University of British Columbia, Vancouver, BC V5Z 1M9, Canada
Author contributions: Wong F and Rayner-Hartley E contributed equally to this work; Byrne MF designed and supervised this research project.
Correspondence to: Michael F Byrne, MD, Clinical Professor of Medicine, Division of Gastroenterology, Vancouver General Hospital/University of British Columbia, 5135-2775 Laurel Street, Vancouver, BC V5Z 1M9, Canada. michael.byrne@vch.ca
Telephone: +1-604-8755640 Fax: +1-604-8755378
Received: October 29, 2013
Revised: January 28, 2014
Accepted: April 30, 2014
Published online: September 14, 2014
Processing time: 324 Days and 18.4 Hours
Revised: January 28, 2014
Accepted: April 30, 2014
Published online: September 14, 2014
Processing time: 324 Days and 18.4 Hours
Core Tip
Core tip:Helicobacter pylori (H. pylori) is the most common chronic infection in humans and has been associated with a variety of extraintestinal manifestations. While evidence exists for associations, the strongest correlation for H. pylori infection is for iron deficiency anemia and immune thrombocytopenic purpura. Symptom improvement noted in urticaria and rosacea with eradication therapy. Possible association with stroke, coronary artery disease, Parkinson’s and Alzheimers.