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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2014; 20(33): 11630-11640
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11630
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11630
Molecular mechanism of hepatitis B virus-induced hepatocarcinogenesis
Mirko Tarocchi, Simone Polvani, Andrea Galli, Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50139 Florence, Italy
Giada Marroncini, Andrea Galli, FiorGen Foundation, 50139 Florence, Italy
Author contributions: Tarocchi M made the literature review and wrote the paper; Polvani S critically revised the manuscript; Marroncini G critically revised the manuscript; Galli A supervised the manuscript.
Supported by Cassa di Risparmio di Firenze (CRF) and FiorGen Foundation
Correspondence to: Andrea Galli, MD, PhD, Professor, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini n°6, 50139 Florence, Italy. andrea.galli@unifi.it
Telephone: +39-55- 4271294 Fax: +39-55-4222409
Received: January 21, 2014
Revised: March 5, 2014
Accepted: April 15, 2014
Published online: September 7, 2014
Processing time: 290 Days and 7.9 Hours
Revised: March 5, 2014
Accepted: April 15, 2014
Published online: September 7, 2014
Processing time: 290 Days and 7.9 Hours
Core Tip
Core tip: Hepatitis B virus (HBV) infection is a global health problem. There is evidence that HBV have a causal role in the development of hepatocellular cancer, but the mechanism leading to the transformation of normal hepatocytes into cancer cells is still intricate. This review will summarize the many mechanisms involved in HBV-related liver carcinogenesis.